Methods and apparatus for a coated anchoring device and/or suture

• US 6,689,153 B1
• Filed: 04/14/2000
• Issued: 02/10/2004
• Est. Priority Date: 04/16/1999
• Status: Expired due to Fees

• Current Assignee: Orthopaedic Biosystems Ltd. Inc. (Smith & Nephew PLC)
• Original Assignee: Orthopaedic Biosystems Ltd. Inc. (Smith & Nephew PLC)
• Inventors: Skiba, Jeffry B.
• Primary Examiner(s): Jackson, Gary
• Application Number:
  US09/548,975
• Time in Patent Office: 1,397 Days
• Field of Search: 606/232
• US Class Current: 606/232
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/06166 Sutures suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M
• CPC Class Codes: A61B 2017/0414 having a suture-receiving opening, e.g. lateral opening lateral eyelet for attaching suture to needle A61B2017/06019
• CPC Class Codes: A61B 2017/044 with a threaded shaft, e.g. screws
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y10S 977/847 Surface modifications, e.g. functionalization, coating

Abstract

A coated/impregnated anchoring device and/or suture to prevent infection, deliver site specific drugs, and deliver human growth factors to the surgical site. The coatings can include anti-microbial agents to prevent or fight infection en route to and at the surgical site. The coatings can also include site specific drugs and/or human growth factors to fight infection, anesthetize tissue and/or bone en route and at the site, promote tissue regeneration, promote bone regeneration, and/or other desired medical processes.

Claims

1. A medical device comprising:

a suture anchor; and

a coating covering a predetermined portion of said suture anchor, wherein said coating includes at least one of an anti-microbial agent or a site specific drug,

wherein said coating includes at least one of;

a silver, a Silicone Rubber Coating, a Fibrin Glue, a Polymethylethacrylate (PMMA) Cement, a Hydroxyanatite Cement, a plurality of PMMA Beads, an Antibiotic Spray, a biodegradable Collagen, a Liposomes, a Collegen Scaffold, a Poylactuc acid microcapsule, a Poly-L-lactic Acid (PLLA) scoffold, a Polyhydroxyethyl methacrylate (pHEMA), a Polwvinylalcholo and a gum arabica blend matrix, or a plurality of Xerogel discs using a solgel process; and

a gentamycin, a benzethonium chloride, an acid antibiotic, a penicillin, a high heparin content polyquaternary polyurethane elastomer, a cephiosporin, a penicillanic acid, a vancomycin, a neomycin, an erythromycin, a streptomycin, a cycloserine, a tetracycline, an aureomycin, a terramycin (oxtetracycline) gentamycin, or a polymyxin B.

2. The device of claim 1 wherein said suture anchor comprises a biocompatible material.

3. The device of claim 2 wherein said biocompatible material includes at least one of a stainless steel, a titanium, a polymer, a bone, or an absorbable.

4. The device of claim 3 wherein said polymer includes at least one of a polyester, a nylon, a poly lactic acid (PLA), a poly-L lactic acid (PLLA), or a poly glycolic acid (PGA).

5. The device of claim 1 further comprising a surgical suture.

6. The device of claim 5 wherein said surgical suture comprises a biocompatible material including at least one of a polymer, a cellulose based (cotton), a protein-cellulose (silk), a processed collagen (catgut), a nylon, a polypropylene, an Aramid, a polyglycolic acid, a polyesters, a polytetraflourethylene, a steel, a copper, a silver, an aluminum, an alloy, a polyglycolide-lactide polymer, a polydioxanone, a polyglecaprone 25, or a polyglyconate.

7. The device of claim 5 wherein a predetermined portion of said surgical suture is coated with at least one of a bactericide, a site specific drug, or a human growth factor.

8. The device of claim 7 wherein said human growth factor includes at least one of a human growth hormone, a morphogenic protein, a Transforming Growth Factor 1, a Recombinant Human TGF-1, a Bone Morphogenetic Protein-1, a Recombinant Human BMP-2, an Osteogenic growth peptide, a Recombinant Human Growth Hormone, a Basic fibroblast Growth Factor, or a Hepatocyte Growth Factor.

9. The device of claim 7 wherein said human growth factor includes at least one of a human growth hormone, a morphogenic protein, a Transforming Growth Factor 1 a Recombinant Human TGF-1, a Bone Morphogenetic Protein-1, a Recombinant Human BMP-2, an Osteogenic growth peptide, a Recombinant Human Growth Hormone, a Basic fibroblast Growth Factor, or a Hepatocyte Growth Factor.

10. The device of claim 5 wherein said surgical suture is impregnated with at least one of an anti-microbial, a site specific drug, or a human growth factor.

11. The device of claim 5 wherein said surgical suture comprises a biocompatible material and is coated with said coating.

12. The device of claim 5 wherein said site specific drug includes at least one of a Tobramycin, a Gentamicin, Cefazolin, a Vancomycin, a Cephalothin, an Oxacillin-nafoillin, a Ceftriaxone, Cefuroxime, an Unspecified cephalosporin, a Bacitracin, an Erythromycin-colistin, or Polymyxin B.

13. The device of claim 12 wherein said coating is impregnated into at least one of said suture anchor or said surgical suture.

14. The device of claim 5 wherein said anti-microbial agent includes a gentamycin, a benzethonium chloride, an acid antibiotic, a penicillin, a high-heparin content polyquaternary polyurethane elastomer, a cephlosporin, a penicillanic acid, a vancomycin, a neomycin, an erythromycin, a streptomycin, a cycloserine, a tetracycline, an aureomycin, a terramycin (oxtetracycline) gentamycin, and a polymyxin B.

15. The device of claim 14 wherein said coating is impregnated into at least one of said suture anchor or said surgical suture.

16. The device of claim 1 wherein said site specific drug includes at least one of a Tobramycin, a Gentamicin, a Cefazolin, a Vancomycin, a Cephalothin, an Oxacillinnafcillin, a Ceftriaxone, a Cefuroxime, an Unspecified cephalosporin, a Bacitracin, an Erythromycin-colistin, or a Polymyxin B.

17. The device of claim 1 wherein the coating is impregnated into the suture anchor.

18. A method for coating a suture anchor comprising the steps of:

coating said suture anchor with a suitable coating; and

configuring said suitable coating to include at least one of controlling infection or delivering site specific drugs,

wherein said suitable coating comprises at least one of;

a silver, a Silicone Rubber Coating, a Fibrin Glue, a Polymethylmethacrylate (PMMA) Cement, a Hydroxyapatite Cement, a plurality of PMMA Beads, an Antibiotic Spray, a Biodegradable Collagen, a Liposomes, a Collagen scaffold, a Poylactuc acid microcansule, a Poly-L-lactic Acid (PLLA) scaffold, a Polyhydroxyethyl methacrylate (pHEMA), a Polyvinylalcohol and a gum arabica blend matrix, or a plurality of Xerogel discs using a sol-gel process; and

a gentamycin, a benzethonium chloride, an acid antibiotic, a penicillin, a high-heparin content polyvuaternary polyurethane elastomer, a cephlosporin, a penicillanic acid, a vancomycin, a neomycin, an erytbromycin, a streptomycin, a cycloserine, a tetracycline, an aureomycin, a terramycin (oxtetracycline) gentamycin, or polymyxin B.

19. The method of claim 18 further comprising the step of coating a suture with said suitable coating.

20. The method of claim 19 wherein said suture comprises a biocompatible material including at least one of a polymer, a cellulose based (cotton), a protein-cellulose (silk), a processed collagen (catgut), a nylon, a polypropylene, an Aramid, a polyglycolic acid, a polyesters, a polytetraflourethylene, a steel, a copper, a silver, an aluminum, an alloy, a polyglycolide-lactide polymer, a polydioxanone, a polyglecaprone 25, or a polyglyconate.

21. The method of claim 19, wherein said suture comprises braided filaments having interstices and said suitable coating covers a predetermined portion of said interstices of said suture.

22. The method of claim 21 further comprising impregnating said suitable coating into said suture.

23. The method of claim 19 further comprising impregnating said suitable coating into at least one of said suture anchor or said suture.

24. The method of claim 19 wherein said suitable coating comprises a human growth factor including a human growth hormone, a morphogenic protein, a Transforming Growth Factor 1, a Recombinant Human TGF-1, a Bone Morphogenetic Protein-1, a Recombinant Human BMP-2, an Osteogenic growth peptide, a Recombinant Human Growth Hormone, a Basic fibroblast Growth Factor, or a Hepatocyte Growth Factor.

25. The method of claim 18 wherein said suture anchor comprises a biocompatible material wherein said biocompatible material includes at least one of a stainless steel, a titanium, a polymer, a bone, or an absorbable.

26. The method of claim 25 wherein said polymer includes at least one of a polyester, a nylon, a poly lactic acid (PLA), a poly-L lactic acid (PLLA), or a poly galactic acid (PGA).

27. The method of claim 18 wherein said suitable coating comprises at least one site specific drug including a Tobramycin, a Gentamicin, a Cefazolin, a Vancomycin, a Cephalothin, an Oxacillin-nafcillin, a Ceftriaxone, a Cefuroxime, an Unspecified cephalosporin, a Bacitracin, an Erythromycin-colistin, or a Polymyxin B.

28. The method of claim 18 wherein:

said suture comprises braided filaments having interstices and said suitable coating covers a predetermined portion of said interstices of said suture.

29. The method of claim 28 further comprising impregnating said suitable coating into at least one of said suture anchor or said suture.

30. The method of claim 18 wherein coating the suture anchor includes impregnating the suitable coating into the suture anchor.