Chromatin regulator genes
First Claim
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1. An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
- (a) a polynucleotide encoding amino acids 251-412 of SEQ ID NO;
4;
(b) a polynucleotide encoding amino acids 1-412 of SEQ ID NO;
4; and
(c) a polynucleotide complementary to the polynucleotide of (a) or (b).
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Abstract
The invention concerns the deregulation of the chromatin-regulator genes which have a SET domain, such deregulation being of importance in certain cancer conditions. These genes can be used in the diagnosis and therapy of such conditions.
28 Citations
15 Claims
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1. An isolated nucleic acid molecule comprising a polynucleotide selected from the group consisting of:
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(a) a polynucleotide encoding amino acids 251-412 of SEQ ID NO;
4;
(b) a polynucleotide encoding amino acids 1-412 of SEQ ID NO;
4; and
(c) a polynucleotide complementary to the polynucleotide of (a) or (b). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
(a) the isolated DNA molecule of claim 1; and
(b) expression control sequences.
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10. A host cell comprising the isolated nucleic acid molecule of claim 1.
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11. The host cell of claim 10 that is prokaryotic.
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12. The host cell of claim 10 that is eukaryotic.
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13. The host cell of claim 10 wherein said isolated nucleic acid molecule is operably associated with a heterologous regulatory sequence.
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14. A method of producing a polypeptide that comprises culturing the host cell of claim 10 under conditions such that said polypeptide is expressed, and recovering said polypeptide.
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15. A process for the production of a polypeptide comprising:
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(a) culturing the host cell of claim 10 under conditions that express said polypeptide; and
(b) recovering said polypeptide.
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Specification