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Indicator of hemolysis

  • US 6,689,612 B2
  • Filed: 05/03/2002
  • Issued: 02/10/2004
  • Est. Priority Date: 06/12/1996
  • Status: Expired due to Fees
First Claim
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1. A method for producing a corrected predicted value for an indicator of hemolysis in a sample, in the presence of methemoglobin (metHb), said method comprising the steps of:

  • i) developing a first primary calibration algorithm for one of a total hemoglobin (Hb), an oxy-hemoglobin (oxy-Hb), or a total hemoglobin-methemoglobin (Hb-methb), for predicting a first value for one of said total Hb, said oxy-Hb, or said total Hb-metHb, in said sample wherein said total Hb, said oxy-Hb, or said total Hb-metHb serves as an indicator of hemolysis and said example;

    ii) deriving a second primary calibration algorithm for said met-Hb, for predicting a second value for said met-Hb in said sample; and

    iii) adding said predicted second value for said met-Hb to one said predicted first value for total Hb, said predicted first value for oxy-Hb, or said predicted first value for total Hb-metHb, to produce said corrected predicted value for an indicator or hemolysis.

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