Method and system for physiological gating of radiation therapy

• US 6,690,965 B1
• Filed: 11/14/2000
• Issued: 02/10/2004
• Est. Priority Date: 10/23/1998
• Status: Expired due to Term

• Current Assignee: Varian Medical Systems Incorporated (Siemens AG)
• Original Assignee: Varian Medical Systems Incorporated (Siemens AG)
• Inventors: Mansfield, Stanley, Mostafavi, Hassan, Riaziat, Majid L.
• Primary Examiner(s): MANTIS MERCADER, ELENI M
• Application Number:
  US09/712,724
• Time in Patent Office: 1,183 Days
• Field of Search: 600/407, 600/587, 600/411, 600/428, 600/473, 600/476, 600/477, 600/437, 600/427, 600/429, 600/413, 600/426, 600/534, 600/538, 600/529, 600/301, 606/130, 250/349, 250/358.1, 250/363.02, 378/65, 378/62, 378/69, 378/205, 345/619-634
• US Class Current: 600/428
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 6/463 characterised by displaying multiple images or images and diagnostic data on one display
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61N 2005/1059 using cameras imaging the patient
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1064 for adjusting radiation treatment in response to monitoring
• CPC Class Codes: A61N 5/1068 Gating the beam as a function of a physiological signal

Abstract

A method and system for physiological gating for radiation therapy is disclosed. According to an aspect, the invention comprises the use of an optical or video image system to measure regular physiological movement of a patient'"'"'s body. The image data can be used to quantify voluntary or involuntary motion of the patient that may affect the delivery of radiation to a target tissue. A gating signal can be generated to suspend delivery of radiation upon certain threshold event detected in the physiological movement.

Claims

1. A system for determining one or more treatment intervals for radiation therapy comprising:

an imaging system for generating image data representative of an internal region of a patient'"'"'s body;

an instrument for generating motion information relating to physiological movement of the patient'"'"'s body; and

a user interface configured to synchronously display in a single display the image data with a motion signal chart the motion signal chart presenting a representation of the motion information and representing physiological movement during a measurement time period;

wherein the user interface is further configured for allowing a gating signal chart to be determined based on the image data and the motion signal chart, the gating signal chart representing one or more treatment intervals.

2. The system of claim 1 in which the imaging system comprises a fluoroscopic imaging system.

3. The system of claim 1 in which the instrument comprises one or more cameras configured to detect the physiological movement.

4. The system of claim 1 in which a simulated treatment interval is defined over the motion information, and in which the image data is displayed during the simulated treatment interval.

5. The system of claim 4 in which the simulated treatment interval is dynamically adjustable.

6. The system of claim 1 further comprising a processor for generating digital analysis signals, the digital analysis signals comprising results of digital analysis to quantify motion of an internal structure shown in the image data.

7. The system of claim 6, wherein the processor is configured to generate the digital analysis signals by performing digital subtraction of image frames.

8. The system of claim 1, wherein the single display comprises a monitor screen.

9. The system of claim 8, wherein the monitor screen comprises a first region for displaying a representation of the image data, and a second region for displaying the motion signal chart.

10. A system for determining one or more treatment intervals in a planning phase of a treatment, comprising:

means for recording image data representative of internal tissue targeted for irradiation;

means for generating motion data representative of physiological movement of a patient;

means for synchronously displaying in a single display the image data with a motion signal chart, the motion signal chart presenting a representation the generated motion data and representing physiological movement during a measurement time period; and

means for determining a gating signal chart based on the image data and the motion signal chart, the gating signal chart representing one or more treatment intervals.

11. The system of claim 10, further comprising means for setting a desired boundary for the treatment interval.

12. The system of claim 11, wherein the means for displaying is configured to display the image data only when the motion data is within the desired boundary of the treatment interval.

13. The system of claim 11, wherein the means for setting comprises a user interface in which a user can set a border around a region of interest in an image.

14. The system of claim 13, wherein the border has a shape of a box.

15. The system of claim 13, wherein the border has a shape that resembles that of a tumor.

16. The system of claim 10, further comprising means for analyzing motion of a tissue during the physiological movement.

17. The system of claim 16, wherein the means for analyzing is configured to perform digital subtraction of image frames.

18. The system of claim 10, further comprising

means for providing a preset movement margin threshold; and

means for analyzing the motion data to determine an optimal gating threshold of the treatment interval to achieve the preset movement margin threshold.

19. The system of claim 10, further comprising means for performing verification to validate a gating threshold setting of the treatment interval.

20. The system of claim 10, wherein the means for recording image data comprises means for recording video data.

21. The system of claim 10, wherein the means for recording image data comprises means for obtaining a static image.

22. The system of claim 10, wherein the means for recording image data comprises means for configuring a positional geometry of an imaging system to correspond to a projection geometry of a radiation beam source.

23. The system of claim 10, wherein the means for synchrononsly displaying comprises a monitor screen.

24. The system of claim 23, wherein the monitor screen comprises a first region for displaying a representation of the image data, and a second region for displaying the motion signal chart.

25. A method for determining one or more treatment intervals for radiation therapy comprising:

recording image data representative of internal tissue targeted for irradiation;

generating motion data representative of a physiological movement that occurs while image data is being recorded;

synchronously displaying the image data with a motion signal chart, the motion signal chart presenting a representation of the generated motion data and representing physiological movement during a measurement time period; and

determining a gating signal chart based on the image data and the motion signal chart, the gating signal chart representing one or more treatment intervals.

26. The method of claim 25, wherein the determining comprises selecting a simulated treatment interval and displaying the image data only when the motion data is within the simulated treatment interval.

27. The method of claim 26 in which the image data is frozen when the motion data is outside the simulated treatment interval.

28. The method of claim 26 further comprising:

adjusting the simulated treatment interval to view a different quantity of image data.

29. The method of claim 25 further comprising:

analyzing the image data to quantify an amount of motion of the targeted tissue during the physiological movement.

30. The method of claim 25 further comprising:

forming a display border around a region of the image data.

31. The method of claim 25 further comprising:

verification of a gating threshold settings of the treatment interval by comparing gated radiation images with reference images created during a planning phase.

32. The method of claim 31 wherein the verification can be performed prior to or at any point during a radiation treatment session.

33. The method of claim 25, wherein the recording image data comprises recording video data.

34. The method of claim 25, wherein the recording image data comprises obtaining a static image.

35. The method of claim 25, wherein the recording image data comprises configuring a positional geometry of an imaging system to correspond to a projection geometry of a radiation beam source.

36. The method of claim 25, wherein the physiological movement comprises chest movement.

37. A method for determining one or more treatment intervals a planning phase of a treatment, comprising:

recording image data representative of internal tissue targeted for irradiation;

generating motion data representative of physiological movement of a patient;

synchronously displaying the image data with a motion signal chart, the motion signal chart presenting a representation of the generated motion data and representing physiological movement during a measurement time period; and

determining a gating signal chart based on the image data and the motion signal chart, the gating signal chart representing one or more treatment intervals.

38. The method of claim 37, further comprising setting a desired boundary for the treatment interval.

39. The method of claim 38, wherein the image data is displayed only when the motion data is within the desired boundary of the treatment interval.

40. The method of claim 38, wherein the setting comprises forming a border around a region of interest in a display.

41. The method of claim 40, wherein the border has a shape of a box.

42. The method of claim 40, wherein the border has a shape that resembles that of a tumor.

43. The method of claim 37, wherein the determining is performed based on a portion of the motion data.

44. The method of claim 43, wherein the physiological movement comprises chest movement.

45. The method of claim 37, further comprising analyzing motion of a tissue during the physiological movement.

46. The method of claim 45, wherein the analyzing comprises performing digital subtraction of image frames.

47. The method of claim 37, further comprising

providing a preset movement margin threshold; and

analyzing the motion data to determine an optimal boundary of the treatment interval to achieve the preset movement margin threshold.

48. The method of claim 37, further comprising performing verification to validate a gating threshold setting of the treatment interval.

49. The method of claim 37, wherein the recording image data comprises recording video data.

50. The method of claim 37, wherein the recording image data comprises obtaining a static image.

51. The method of claim 37, wherein the recording image data comprises configuring a positional geometry of an imaging system to correspond to a projection geometry of a radiation beam source.

52. The method of claim 37, wherein the determining comprises selecting a simulated treatment interval, and displaying the image data only when the motion data is within the simulated treatment interval.

53. The method of claim 52, wherein the determining further comprises freezing the image data when the motion data is outside the simulated treatment interval.