Calibration of pumps, such as blood pumps of dialysis machine

• US 6,691,047 B1
• Filed: 03/16/2000
• Issued: 02/10/2004
• Est. Priority Date: 03/16/2000
• Status: Expired due to Term

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Aksys Ltd.
• Inventors: Fredericks, Chris N.
• Primary Examiner(s): Hoff, Marc S.
• Assistant Examiner(s): Desta, Elias
• Application Number:
  US09/527,327
• Time in Patent Office: 1,426 Days
• Field of Search: 702/19, 702/21, 702/31, 702/32, 702/45, 702/47, 702/50, 702/55, 702/85, 702/100, 702/98, 702/104, 702/105, 702/114, 702/138-140, 702/182, 702/183, 702/188, 702/FOR.115, 702/119, 702/134, 702/135, 702/143, 702/156, 702/163, 702/170, 702/171, 604/4.01, 604/6.11, 604/6.61, 604/29, 604/30, 604/67, 604/118, 604/246, 604/247, 604/151, 604/31, 731/68, 417/63, 417/22, 417/18, 422/33, 422/81, 422/82, 422/13, 422/112, 422/113, 422/118, 422/208, 422/226, 128/867, 128/203.14, 128/204.18, 128/900, 128/DIG.12
• US Class Current: 702/47
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3351 Controlling upstream pump pressure
• CPC Class Codes: A61M 2205/3382 Upper level detectors
• CPC Class Codes: A61M 2205/3386 Low level detectors
• CPC Class Codes: A61M 2205/3396 Reservoirs being alternately filled and emptied for measuring flow rate or delivered volume
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/70 with testing or calibration facilities
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/279 Peristaltic pumps, e.g. roller pumps
• CPC Class Codes: A61M 60/37 Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/508 Electronic control means, e.g. for feedback regulation
• CPC Class Codes: A61M 60/851 Valves

Abstract

A method of calibrating a pump that is subject to variations in flow rate based on inlet pressure variations, such as a peristaltic pump found in medical instruments. The pressure at the inlet of the pump is measured and recorded during prior uses of the pump. A mean or average inlet pressure is derived from the measurements, either directly or indirectly from the measurements of using regression techniques, as a way of forecasting the inlet pressure during the next use of the pump. The pump is then calibrated at an inlet pressure that is set or adjusted to match the mean or average inlet pressure. The calibration is thus accurately performed for the pump, and is independent of the absolute accuracy of the inlet pressure sensor.

Claims

1. A method of operating a pump subject to repeated use, said pump placed in a fluid conduit, comprising the steps of:

(a) recording inlet pressures in said fluid conduit during a previous use of said pump;

(b) deriving, from said recordings of inlet pressure, a mean inlet pressure during said previous use of said pump;

(c) calibrating the flow rate of said pump, said step of calibrating performed while said inlet pressure to said fluid conduit is maintained at said mean inlet pressure; and

(d) subsequently using said pump.

2. The method of claim 1, wherein said pump comprises a blood pump of a medical instrument.

3. The method of claim 2, wherein said blood pump is part of an extracorporeal blood circuit of a dialysis machine, and wherein said repeated uses of said pump comprise repeated uses of said pump in conjunction with dialysis sessions performed on a patient by said extracorporeal circuit and said dialysis machine.

4. The method of claim 1, wherein said step of calibrating comprises the steps of:

moving a known volume of fluid with said pump at a predetermined pump revolutions per minute;

measuring the time taken to move said known volume of fluid; and

determining the volume of fluid moved by said pump per revolution;

wherein said step of moving is performed while said inlet pressure to said fluid conduit is maintained at said mean inlet pressure.

5. The method of claim 4, further comprising the steps of placing a restriction between a source of said known volume of fluid and the inlet to said fluid conduit, and adjusting said restriction so as to create an inlet pressure in said fluid conduit substantially matching said mean inlet pressure.

6. The method of claim 1, wherein:

said blood pump is incorporated into a medical instrument having a central processing unit,

said step of recording comprises the step of reading measurements of inlet pressure to a computer-readable storage medium associated with said central processing unit, and

said step of deriving is performed by said central processing unit retrieving said measurements from said storage medium and executing a software program to derive said mean inlet pressure from said measurements.

7. The method of claim 1, wherein during said step of calibrating the flow rate of said pump, said inlet pressure is varied periodically about said mean inlet pressure.

8. A method of calibrating a peristaltic blood pump of a hemodialysis machine, said hemodialysis machine having an extracorporeal circuit comprising an arterial line, a venous line, and a dialyzer, wherein said blood pump pumps blood from a patient through said arterial line and dialyzer and delivers said blood back to said patient via said venous line, comprising the step of:

recording inlet pressures in said arterial line during dialysis sessions for said patient;

deriving from said recorded inlet pressures a calibration inlet pressure P_c to be used for calibration of said blood pump;

adjusting the inlet pressure of said arterial line and moving a known volume of fluid with said blood pump while maintaining said inlet pressure of said arterial line at said pressure P_c to thereby calibrate said pump at said pressure P_c.

9. The method of claim 8, wherein said pressure P_c is derived by regression of said recorded inlet pressures.

10. The method of claim 8, wherein said pressure P_c is derived by averaging of said recorded inlet pressures.

11. The method of claim 8, wherein said step of moving comprises the step of moving a known volume of fluid by said blood pump with said blood pump operating at a predetermined rate of revolutions per minute.

12. The method of claim 11, wherein at least a portion of said known volume of fluid is stored in an ultrafiltration tank and drawn from said ultrafiltration tank through said extracorporeal circuit to a drain.

13. The method of claim 10, further comprising the steps of placing a restriction in a fluid line connecting said ultrafiltration tank to said arterial line, and adjusting said restriction during said step of moving so as to create an inlet pressure in said arterial line substantially matching said pressure P_c.

14. The method of claim 13, said dialysis machine comprises central processing unit and a computer-readable storage medium associated with said central processing unit, and wherein said step of measurements of inlet pressure are recorded on said computer-readable storage medium, and said derived volume per revolution is performed by said central processing unit by retrieving said measurements from said storage medium and executing a software program to calculate said volume per revolution.

15. The method of claim 8, further comprising the step of verifying the calibration of said pump to determine if said calibration is within a specified range.

16. A method of operating a dialysis machine having an extracorporeal circuit comprising a blood pump, an arterial line, a venous line and a dialyzer, comprising the steps of:

calibrating said blood pump at an inlet calibration pressure P_c derived from recorded inlet pressures in said arterial line from an at least one previous dialysis session of said dialysis machine to thereby derive a relationship for said blood pump between said inlet calibration pressure P_c and a known volume of fluid moved by said blood pump per revolution at said inlet calibration pressure P_c, and

during a subsequent dialysis session of said dialysis machine, adjusting the speed of said blood pump to achieve a substantially constant flow of blood through said extracorporeal circuit regardless of changes in the inlet pressure of said arterial line during said use of said dialysis machine.

17. The method of claim 16, wherein said step of calibrating is performed by performing the following steps:

recording inlet pressures in said arterial line during previous dialysis sessions;

deriving from said recorded inlet pressures said calibration inlet pressure P_c;

adjusting the inlet pressure of said arterial line and moving a known volume of fluid with said blood pump while maintaining said inlet pressure of said arterial line at said pressure P_c to thereby calibrate said pump at said pressure P_c.

18. The method of claim 16, wherein said step of adjusting is performed for at least one minute during the treatment of a patient during said subsequent dialysis session.

19. The method of claim 16, wherein said step of adjusting is performed for at least 10 minutes.

20. A method of operating a blood pump subject to repeated use, said blood pump placed in a fluid conduit comprising an extracorporeal circuit, comprising the steps of:

(a) recording inlet pressures in said fluid conduit during at least one previous use of said pump;

(b) deriving, from said recordings of inlet pressure, a mean inlet pressure during said at least one previous use of said pump;

(c) using a computed volume of fluid moved by said blood pump per revolution at said mean inlet pressure to calibrate said pump.