Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis
First Claim
1. A catheter for delivering agents to a defined biological space in vivo comprising:
- an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip configured to pierce a biological membrane proximate to the biological space;
an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip;
said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft; and
at least one deployable support member non-detachably secured to at least one of said inner catheter shaft and said outer catheter shaft.
1 Assignment
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Accused Products
Abstract
A catheter and a method for using the catheter for site specific delivery of agents to or collecting agents from biological spaces. The catheter includes an inner shaft longitudinally movable within an outer shaft, each shaft having at least one balloon and at least one lumen formed therein. The catheter prevents leaking through a biological membrane by sealing the catheter tip passageway through the biological membrane with inflatable balloons on either side of the biological membrane. Further, the inflated balloons secure the position of the catheter relative to the biological membrane and the biological space targeted for therapy or diagnosis.
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Citations
56 Claims
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1. A catheter for delivering agents to a defined biological space in vivo comprising:
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an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip configured to pierce a biological membrane proximate to the biological space;
an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip;
said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft; and
at least one deployable support member non-detachably secured to at least one of said inner catheter shaft and said outer catheter shaft. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A catheter for delivering agents to a defined biological space in vivo comprising:
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an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip;
an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip;
said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft;
said outer catheter shaft comprising a proximal pusher portion and a distal end portion, said proximal pusher portion configured to be retractable from said distal end portion to uncover said inner catheter shaft; and
at least one deployable support member non-detachably attached to at least one of said inner catheter shaft and said outer catheter shaft.
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31. A method for delivering agents to a defined biological space in vivo comprising:
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providing a catheter comprising an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip, and having an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip, said inner catheter shaft disposed within and movable with respect said outer catheter shaft and disposing at least one deployable support member non-detachable positioned on at least one of said inner catheter shaft and said outer catheter shaft;
guiding said catheter to a surface of the biological space in vivo;
piercing a surface membrane of the biological space with said inner catheter distal tip;
deploying said at least one deployable support member;
infusing an agent into the biological space;
retracting said at least one deployable support member; and
withdrawing said catheter from said biological space. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
deploying positioned on said inner catheter shaft; and
inflating at least one inflatable sealing balloon positioned on said outer catheter shaft.
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56. The method of claim 31, wherein said catheter further comprises a proximal pusher portion and a distal end portion and said proximal portion is retractable from said distal end portion to uncover said inner catheter shaft.
Specification