Apparatus for cell necrosis

• US 6,692,488 B2
• Filed: 04/12/2001
• Issued: 02/17/2004
• Est. Priority Date: 01/23/1998
• Status: Expired due to Term

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Innercool therapies Incorporated (Taxus Cardium Pharmaceuticals Group, Inc.)
• Inventors: Lasheras, Juan C., Dobak, John D. III
• Primary Examiner(s): Leubecker, John P.
• Application Number:
  US09/834,068
• Publication Number:
  US 20020007179A1
• Time in Patent Office: 1,041 Days
• Field of Search: 606/20-26, 607/96, 607/104-106, 607/113
• US Class Current: 606/23
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid
• CPC Class Codes: A61F 2007/0056 for cooling
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities

Abstract

A heat transfer device has first and second elongated, articulated segments, each having a turbulence-inducing exterior surface. A flexible joint connects the first and second elongated, articulated segments. An inner coaxial lumen is disposed within the first and second elongated, articulated segments. The inner coaxial lumen is capable of transporting a pressurized working fluid to a distal end of the first elongated, articulated segment

Claims

1. A heat transfer device for necrosing tissue comprising:

first and second elongated segments, one of said first second elongated segments having clockwise invaginations and another of said first and second elongated segments having counterclockwise invaginations, and one of said first or second elongated segments providing a closed end of the hear transfer device;

a bellows connecting the first and second elongated segments; and

a tubular conduit disposed within and extending substantially through the first and second elongated segments, the conduit having an insulated inner lumen for transporting a perfluorocarbon working fluid to a distal end of said one of said first or second elongated segments providing a closed end of the heat transfer device.

2. The device of claim 1, wherein the first and second elongated segments each have an irregular interior surface to induce mixing within a pressurized working fluid.

3. The device of claim 1, wherein the first and second elongated segments have a surface coating to inhibit clot formation.

4. The device of claim 1, wherein the first and second elongated segments are formed from highly conductive material.

5. The device of claim 2 further comprising:

a coaxial supply catheter having an inner catheter lumen coupled to the inner coaxial lumen within the first and second elongated segments; and

a working fluid supply configured to dispense a perfluorocarbon working fluid and having an output coupled to the inner catheter lumen.

6. The device of claim 5, wherein the working fluid supply is configured to produce the pressurized working fluid at less than about 0°

C.

7. The device of claim 2, further comprising:

at least one additional elongated segment; and

at least one additional bellows connecting the at least one additional elongated segment to one of the first and second elongated segments.