Composite sponge wound dressing made of β-Chitin and Chitosan and method for producing the same

• US 6,693,180 B2
• Filed: 04/04/2002
• Issued: 02/17/2004
• Est. Priority Date: 04/04/2002
• Status: Active Grant

• Current Assignee: Taiwan Textile Research Institute
• Original Assignee: China Textile Institute
• Inventors: Lee, Jui-Sheng, Hsu, Chun-Yuan, Lin, Wei-Hsin
• Primary Examiner(s): Barts, Samuel
• Assistant Examiner(s): Henry, Michael C.
• Application Number:
  US10/115,007
• Publication Number:
  US 20030190346A1
• Time in Patent Office: 684 Days
• Field of Search: 514/55, 514/54, 536/20, 536/55.1, 536/18.7, 536/17.2, 536/55, 536/123.1, 536/55.3
• US Class Current: 536/20
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08J 2201/0484 the liquid phase being aqueous
• CPC Class Codes: C08J 2305/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C08J 9/26 by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
• CPC Class Codes: C08L 2203/02 for biomedical use
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

The present invention relates to a composite sponge wound dressing and method for producing the same. Chitosan and β-Chitin is mixed in a specific ratio for forming the sponge for wound repairing. Particularly, when said ratio is between 0.1˜1, the composite sponge wound dressing has a better absorption and tensile strength.

Claims

1. A method for producing composite sponge wound dressing made of β

-Chitin and Chitosan, which comprises the steps of;

a.) providing a β

-Chitin and a Chitosan;

b.) putting said β

-Chitin in deionized water (D.I. Water);

c.) blending said β

-Chitin in high speed for forming a hydrogel β

-Chitin;

d.) solving said Chitosan by an acid liquid;

e.) filtering said Chitosan;

f.) mixing said hydrogel β

-Chitin from step c and said Chitosan from step e;

g.) forming a sponge by freeze-drying;

h.) immersing said sponge in an alkaline liquid for forming salt by neutralization;

i.) cleaning and removing said salt with water until said sponge becoming neutral;

j.) cleaning said sponge with D.I. Water repeatedly; and

k.) producing a composite sponge wound dressing made of β

-Chitin and Chitosan by vacuum drying.

2. The method of claim 1, wherein the sequence of the steps b, c and steps d, e is synchronizing.

3. The method of claim 1, the step f mixing said Chitosan and said hydrogel β

-Chitin further accords with a specific ratio of Chitosan and β

-Chitosan, wherein said ratio is between 0.1˜

1.

4. The method of claim 3, wherein said ratio is between 0.125˜

0.5.

5. The method of claim 1, wherein said β

-Chitin is short staple β

-Chitin.

6. The method of claim 1, wherein said Chitosan is membrane Chitosan.

7. The method of claim 1, wherein said acid liquid is 2% acetic acid.

8. The method of claim 1, wherein said alkaline liquid is 5% sodium hydroxide (NaOH) liquor.

9. The method of claim 1, after forming said composite sponge wound dressing made of β

-Chitin and Chitosan, further comprises the step of covering said composite sponge wound dressing with a protection dressing for wound repairing.

10. The method of claim 9, wherein said protection dressing is selected from a group of PU film, bandage, non-woven, fabric, paper, and tape.