Choice of wavelengths for multiwavelength optical imaging

• US 6,694,159 B2
• Filed: 11/02/2001
• Issued: 02/17/2004
• Est. Priority Date: 07/16/2001
• Status: Expired due to Term

• Current Assignee: Softscan Healthcare Group Limited
• Original Assignee: Art Advanced Research Technologies Incorporated (Microsoft Corporation)
• Inventors: Hall, David, Kohl-Bareis, Mathias
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): McCrosky, David J.
• Application Number:
  US09/985,436
• Publication Number:
  US 20030078479A1
• Time in Patent Office: 837 Days
• Field of Search: 600/310, 600/476, 600/477, 600/322, 600/323, 600/473, 600/475, 250/363.02, 250/252.1, 356/457, 700/28
• US Class Current: 600/310
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06

Abstract

The present invention relates to a method for wavelength selection in a multi-wavelength TPSF-based optical imaging system. This consists of identifying several chromophores in a highly turbid medium and selecting optimized wavelengths whereby using these wavelengths optimizes the deduction of the chromophore concentrations. Such chromophore concentrations may be combined to deduce other properties of the turbid medium.

Claims

1. In a method of optical imaging of a turbid media using a plurality of discrete wavelengths in an optical imaging system, a method of optimizing system parameters comprising the steps of:

selecting a set of chromophores for characterizing a property of the turbid media;

defining parameters of the system including at least a number of said discrete wavelengths, a value of each of said wavelengths, source power and detector aperture for each of said wavelengths, a choice of image algorithm and source/detector geometries, a choice of source and detector and noise characteristics;

fixing a value of all of said parameters except a plurality of said parameters of the system to be optimized; and

determining an optimal value for each of said parameter values to be optimized as a function of a performance of the system in measuring a concentration of said chromophores in said turbid media for characterizing said property as a whole.

2. The method of claim 1, wherein said imaging is medical imaging, said highly turbid medium being body tissue and said property is physiological.

3. The method of claim 1, wherein said parameter values to be optimized comprise a value of each of said wavelengths.

4. The method of claim 3, wherein said parameter values to be optimized further comprise said number of said discrete wavelengths.

5. The method of claim 4, wherein said step of determining comprises fixing said number of discrete wavelengths at each of a plurality of numbers, and determining an optimized performance of the system in measuring a concentration of said chromophores in said turbid media at each of said plurality of wavelengths, and selecting one of said plurality of numbers having a best optimized performance.

6. The method of claim 3, wherein said step of determining an optimal value for each of said parameters comprising minimizing a condition number of a matrix of specific absorption coefficients of said chromophores as a function of wavelength.

7. The method of claim 4, wherein said step of determining an optimal value for each of said parameters comprises minimizing a condition number of a matrix of specific absorption coefficients of said chromophores as a function of wavelength.

8. The method of claim 5, wherein said step of determining an optimal value for each of said parameters comprises minimizing a condition number of a matrix of specific absorption coefficients of said chromophores as a function of wavelength.

9. The method of claim 1, wherein said step of determining comprises empirically determining said performance of the system for a range of said values for each of said parameter values to be optimized.

10. The method of claim 2, wherein said plurality of chromophores comprise at least oxy-hemoglobin and deoxy-hemoglobin.

11. The method of claim 10, wherein said chromophores are water, lipids, oxy-hemoglobin and deoxy-hemoglobin.

12. The method of claim 10, wherein said body tissue is breast tissue.

13. The method of claim 10, wherein said number of wavelengths selected is from 2 to 4.

14. The method of claim 13, wherein said number is 4.

15. The method of claim 11, wherein values of said wavelengths are 760 nm, 780 nm, 830 nm and 850 nm.

16. The method of claim 1, wherein the step of determining an optimal value of said parameters to be optimized comprises:

deriving an inherent wavelength-dependent sensitivity to noise in calculating said chromophore concentrations, and

determining an optimal correlation of said sensitivity and at least one other of said parameters.

17. The method of claim 16, wherein one of said parameters to be optimized is a distribution of an acquisition time at each of said wavelengths.

18. The method of claim 1, wherein one of said parameters to be optimized is a distribution of an acquisition time at each of said wavelengths.

19. The method of claim 18, further comprising a step of determining a minimum value for said acquisition time at which said performance of said system attains a minimum threshold value.

20. The method of claim 1, wherein one of said parameters to be optimized is at least one of said source power and said detector aperture for each of said wavelengths.

21. The method of claim 20, further comprising a step of determining a minimum value for an acquisition time at which said performance of said system attains a minimum threshold value.