Choice of wavelengths for multiwavelength optical imaging
First Claim
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1. In a method of optical imaging of a turbid media using a plurality of discrete wavelengths in an optical imaging system, a method of optimizing system parameters comprising the steps of:
- selecting a set of chromophores for characterizing a property of the turbid media;
defining parameters of the system including at least a number of said discrete wavelengths, a value of each of said wavelengths, source power and detector aperture for each of said wavelengths, a choice of image algorithm and source/detector geometries, a choice of source and detector and noise characteristics;
fixing a value of all of said parameters except a plurality of said parameters of the system to be optimized; and
determining an optimal value for each of said parameter values to be optimized as a function of a performance of the system in measuring a concentration of said chromophores in said turbid media for characterizing said property as a whole.
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Abstract
The present invention relates to a method for wavelength selection in a multi-wavelength TPSF-based optical imaging system. This consists of identifying several chromophores in a highly turbid medium and selecting optimized wavelengths whereby using these wavelengths optimizes the deduction of the chromophore concentrations. Such chromophore concentrations may be combined to deduce other properties of the turbid medium.
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Citations
21 Claims
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1. In a method of optical imaging of a turbid media using a plurality of discrete wavelengths in an optical imaging system, a method of optimizing system parameters comprising the steps of:
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selecting a set of chromophores for characterizing a property of the turbid media;
defining parameters of the system including at least a number of said discrete wavelengths, a value of each of said wavelengths, source power and detector aperture for each of said wavelengths, a choice of image algorithm and source/detector geometries, a choice of source and detector and noise characteristics;
fixing a value of all of said parameters except a plurality of said parameters of the system to be optimized; and
determining an optimal value for each of said parameter values to be optimized as a function of a performance of the system in measuring a concentration of said chromophores in said turbid media for characterizing said property as a whole. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
deriving an inherent wavelength-dependent sensitivity to noise in calculating said chromophore concentrations, and determining an optimal correlation of said sensitivity and at least one other of said parameters.
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17. The method of claim 16, wherein one of said parameters to be optimized is a distribution of an acquisition time at each of said wavelengths.
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18. The method of claim 1, wherein one of said parameters to be optimized is a distribution of an acquisition time at each of said wavelengths.
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19. The method of claim 18, further comprising a step of determining a minimum value for said acquisition time at which said performance of said system attains a minimum threshold value.
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20. The method of claim 1, wherein one of said parameters to be optimized is at least one of said source power and said detector aperture for each of said wavelengths.
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21. The method of claim 20, further comprising a step of determining a minimum value for an acquisition time at which said performance of said system attains a minimum threshold value.
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