Fault-tolerant detector for gamma ray imaging

• US 6,694,172 B1
• Filed: 08/31/2001
• Issued: 02/17/2004
• Est. Priority Date: 06/23/2001
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Gagnon, Daniel, Griesmer, Jerome J.
• Primary Examiner(s): MANTIS MERCADER, ELENI M
• Application Number:
  US09/943,912
• Time in Patent Office: 900 Days
• Field of Search: 600/407, 600/431, 600/436, 600/427, 250/370.08, 250/370.01, 250/370.13, 250/303, 250/371, 250/362, 250/363.07, 250/363.08, 250/363.09, 250/363.1, 250/363.02, 250/369, 250/308, 250/363.04, 604/27-28, 378/207, 378/901, 378/62-63, 378/4
• US Class Current: 600/436
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: G01T 1/2928 using solid state detectors

Abstract

A nuclear imaging apparatus includes a radiation detector comprising an array (18) of solid state detector elements (22) responsive to incident gamma radiation by emitting a current spike. A pixel correction processor (44) detects defective detector elements in the array and a flood correction circuit (66) corrects detected radiation events (70) based on sensitivity differences between a plurality of groupings of detector elements in the array. A reconstruction processor (76) reconstructs an image representation from the corrected radiation events (74).

Claims

1. A nuclear imaging apparatus comprising:

a radiation detector including a plurality of rows of tiles of detector elements, each of the detector elements generating an output pulse in response to each detected radiation event;

a rotor which rotates the radiation detector;

an analyzer which compares the response of each detector element with preselected response criteria when the radiation detector is subjected to a calibration radiation source;

read out electronics which suppresses output pulses from detector elements whose response fails to meet the preselected response criteria;

a plurality of summing circuits, each summing circuit being connected with one of the plurality of rows of tiles of detector elements to generate a sum of the output pulses therefrom during a sampling period;

a correction circuit which adjusts the sums with correction factors, each row having a preselected one of the correction factors after the output pulses from detector elements whose response fails to meet the preselected response criteria are suppressed; and

a reconstruction processor that reconstructs an image representation from the adjusted sums and rotational position of the radiation detector corresponding to each sampling period.

2. The apparatus of claim 1, wherein said correction circuit receives the sums while the detector elements are subjected to a the calibration radiation source, determines a deviation between the sum of each row and a nominal sum, and calculates a corresponding correction factors to correct each sum to the nominal sum.

3. A nuclear imaging apparatus comprising:

a radiation detector comprising an array of solid state detector elements arranged in a plurality of rows of tiles of detector elements, the detectors elements responsive to incident gamma radiation by emitting output pulses;

a pixel correction processor which detects defective detector elements in the array;

means for comparing a spectral response of each detector element with preselected spectral response criteria when the radiation detector is subjected to a calibration radiation source;

read out electronics which suppresses output pulses from defective detector elements whose spectral response fails to meet the preselected response criteria;

a plurality of summing circuits, each summing circuit being connected with one of the plurality of rows of tiles of detector elements to generate a sum of the output pulses therefrom during a sampling period;

a flood correction circuit which corrects detected radiation events based on sensitivity by adjusting the sums with correction factors, each row having a preselected one of the correction factors after the output pulses from defective detector elements are suppressed; and

a reconstruction processor which reconstructs an image representation from the corrected radiation events.

4. The apparatus of claim 3, wherein the flood correction circuit compares the detected radiation events for each row with a nominal number of counts and calculates a corrective weighting factors, one for each row, the corrective weighting factors calculated to scale each row to the nominal number.

5. The apparatus of claim 3, the pixel correction processor including:

a pulse height analyzer for generating an energy spectrum for each pixel;

an a pixel offset correction circuit for normalizing the detector elements with respect to a baseline voltage when no gamma radiation is incident on the radiation detector; and

a gain correction circuit for normalizing the detector elements with respect to pulse height of the current spikes when gamma radiation is incident on the radiation detector.

6. The apparatus of claim 3, wherein:

the pixel correction processor utilizes gamma radiation events received from a known radiation source, the gamma radiation events collected within a wide energy range relative to a collected photopeak; and

the flood correction circuit utilizes gamma radiation events received from the known radiation source, the gamma radiation events collected within a narrow energy range relative to the collected photopeak.

7. The apparatus of claim 6, wherein the flood correction circuit utilizes gamma radiation events collected within an energy window which is 10% of the collected photopeak and which is centered about the photopeak.

8. The apparatus of claim 3, wherein the radiation detector comprises an array of semiconductor crystals selected from cadmium-zinc-telluride crystals and cadmium-telluride crystals.

9. A method of diagnostic imaging of a subject comprising:

exposing a solid state radiation detector array to a known radiation source, the radiation detector comprising a two-dimensional array of detector elements generating a detectable signal responsive to incident gamma radiation, and each detector element comprising a distinct channel;

detecting radiation events at each detector element;

identifying defective and nondefective detector elements and electronically disabling defective detector elements whose response to radiation is outside of preselected specifications;

introducing a radioactive isotope into a subject located in an imaging region;

spinning the radiation detector array according to a preselected spin orbit;

rotating the radiation detector array about a longitudinal axis of the subject;

during said spinning and rotating, detecting radiation events indicative of nuclear decay to generate a plurality of planar projections of an examination region;

weighting the detected radiation events for each row of a plurality of detector elements with weighting factors to generate corrected data after the defective detector elements are disabled;

reconstructing the corrected data into an image representation of the subject in the imaging region.

10. The method of claim 9, further including:

calculating detector element correction values which normalize a spectrum of each nondefective detector element; and

defining an energy window based on the energy resolution of the normalized spectra, the energy window for screening radiation events according to energy;

calculating a the weighting factors for each row of a the plurality of detector elements, the weighting factor scaling each row to a nominal value when the detector is exposed to the known radiation source.

11. The method of claim 10, wherein calculating detector element correction values includes:

calculating an offset value and a gain correction factor for each detector element.

12. The method of claim 10, wherein the energy window is defined as 10% of a collected photopeak, centered about the photopeak.

13. The method of claim 9, wherein identifying defective detector elements includes:

determining whether the number of radiation events detected by each detector element exceeds a preselected threshold value;

recording as defective each detector element for which the preselected threshold value is not exceeded;

generating an energy spectrum for each detector element for which the preselected threshold value is exceeded;

analyzing the generated energy spectra for a preselected degree of energy resolution; and

recording as defective each detector element which lacks the preselected degree of energy resolution.

14. The method of claim 9, wherein the array of detectors elements is a multi-channel cadmium-zinc-telluride detector array.

15. The method of claim 9, wherein the array of detectors elements further comprises:

radiation-absorbing collimator plates disposed parallel to one another for collimating the gamma radiation incident on the radiation detector array.

16. The method of claim 9, wherein spinning includes:

rotating the radiation detector array about an axis extending through a center point of the radiation detector array.

17. A method of calibrating a nuclear imaging device comprising:

exposing a solid state radiation detector to a known radiation source, the radiation detector having a two-dimensional array of detector elements generating a detectable signal responsive to incident gamma radiation, and each detector element defining a distinct channel;

detecting radiation events at each detector element;

defining an energy window based on energy resolution of normalized spectra, the energy window for screening radiation events according to energy;

identifying defective and nondefective detector elements;

calculating detector element correction values which normalize a spectrum of each nondefective detector element; and

calculating a weighting factor for each of a plurality of detector element rows, after the spectra of each nondefective detector element is normalized, the weighting factor scaling each row to a nominal value when the radiation detector is exposed to a the known radiation source.

18. The method of claim 17, wherein the array of detector elements comprises a plurality of tile detector element subarrays, the method further comprising:

identifying one or more rows having a the weighting factor which is outside a preselected range of values; and

rearranging the tile detector element subarrays such that the weighting factor of each of the identified one or more rows falls within said preselected range of values.