Mixed-mode liquid ventilation gas and heat exchange
First Claim
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1. A method of heat exchange within the lungs of a mammal, comprising:
- a. delivering a first volume of oxygenated liquid to the lungs in an amount approximately equal to the functional residual capacity of the lungs, said oxygenated liquid having a temperature below the temperature of the mammal;
b. cycling a second volume of oxygenated liquid into and out of the lungs in an amount less than one third of total lung capacity and at a liquid cycle rate defined by delivering said second volume of oxygenated liquid at a rate of 6 mL/kg/min to 50 mL/kg/min, then removing said second volume of oxygenated liquid at a rate of 12 mL/kg/min to 80 mL/kg/min; and
c. cycling a volume of breathing gas into and out of the lungs at a predetermined gas cycle rate which is independent of the liquid cycle rate.
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Abstract
A novel technique for ventilation and heat exchange is disclosed called Mixed-mode Liquid Ventilation (MMLV). This technique uses an endotracheal catheter to add and remove liquid from the lungs continuously and/or cyclically, and deliver gas at a rate independent of the delivery of liquid. This technique produces small-scale mixing of gas and liquid in the airways, allowing for efficient gas and heat exchange. Medical uses for the technique are disclosed. These uses include induction and reversal of hyperthermia, and hypothermia.
78 Citations
14 Claims
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1. A method of heat exchange within the lungs of a mammal, comprising:
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a. delivering a first volume of oxygenated liquid to the lungs in an amount approximately equal to the functional residual capacity of the lungs, said oxygenated liquid having a temperature below the temperature of the mammal;
b. cycling a second volume of oxygenated liquid into and out of the lungs in an amount less than one third of total lung capacity and at a liquid cycle rate defined by delivering said second volume of oxygenated liquid at a rate of 6 mL/kg/min to 50 mL/kg/min, then removing said second volume of oxygenated liquid at a rate of 12 mL/kg/min to 80 mL/kg/min; and
c. cycling a volume of breathing gas into and out of the lungs at a predetermined gas cycle rate which is independent of the liquid cycle rate. - View Dependent Claims (2, 3)
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4. A method of heat exchange within the lungs of a mammal, comprising:
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a. delivering a first volume of biocompatible liquid to the lungs in an amount approximately equal to the functional residual capacity of the lungs, said biocompatible liquid having a temperature below the temperature of the mammal;
b. cycling a second volume of biocompatible liquid into and out of the lungs in an amount less than one third of total lung capacity and at a liquid cycle rate defined by delivering said second volume of biocompatible liquid at a rate of 6 mL/kg/min to 50 mL/kg/min, then removing said second volume of biocompatible liquid at a rate of 12 mL/kg/min to 80 mL/kg/min; and
c. cycling a volume of breathing gas into and out of the lungs at a predetermined gas cycle rate which is independent of the liquid cycle rate. - View Dependent Claims (5, 6)
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7. A method of heat exchange within the lungs of a mammal, comprising:
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a. delivering a first volume of oxygenated liquid to the lungs in an amount approximately equal to the functional residual capacity of the lungs, said oxygenated liquid having a temperature above the temperature of the mammal;
b. cycling a second volume of oxygenated liquid into and out of the lungs in an amount less than one third of total lung capacity and at a liquid cycle rate defined by delivering said second volume of oxygenated liquid at a rate of 6 mL/kg/min to 50 mL/kg/min, then removing said second volume of oxygenated liquid at a rate of 12 mL/kg/min to 80 mL/kg/min; and
c. cycling a volume of breathing gas into and out of the lungs at a predetermined gas cycle rate which is independent of the liquid cycle rate. - View Dependent Claims (8, 9, 10)
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11. A method of heat exchange within the lungs of a mammal, comprising:
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a. delivering a first volume of biocompatible liquid to the lungs in an amount approximately equal to the functional residual capacity of the lungs, said biocompatible liquid having a temperature above the temperature of the mammal;
b. cycling a second volume of biocompatible liquid into and out of the lungs in an amount less than one third of total lung capacity and at a liquid cycle rate defined by delivering said second volume of biocompatible liquid at a rate of 6 mL/kg/min to 50 mL/kg/min, then removing said second volume of biocompatible liquid at a rate of 12 mL/kg/min to 80 mL/kg/min; and
c. cycling a volume of breathing gas into and out of the lungs at a predetermined gas cycle rate which is independent of the liquid cycle rate. - View Dependent Claims (12, 13, 14)
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Specification
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Current AssigneeCritical Care Research, Inc.
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Original AssigneeCritical Care Research, Inc.
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InventorsFederowicz, Michael, Harris, Steven B., Russell, Sandra R.
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Primary Examiner(s)Lo, Weilun
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Assistant Examiner(s)Erezo, Darwin P.
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Application NumberUS09/543,709Time in Patent Office1,420 DaysField of Search128/203.26, 128/203.25, 128/204.17, 128/204.15, 128/202.26, 128/202.25, 128/201.21, 128/201.13, 128/913, 128/207.14, 128/204.18, 622/593US Class Current128/204.18CPC Class CodesA61F 2007/006 of gasA61F 7/12 Devices for heating or cool...A61M 16/0054 Liquid ventilationA61M 16/107 in the inspiratory pathA61M 16/14 by mixing different fluids,...A61M 16/145 using hollow fibresA61M 19/00 Local anaesthesia syringes ...A61M 2202/0476 Oxygenated solutionsY10S 128/913 Breathable liquids
