Device for analyzing biological and medical specimens

• US 6,696,021 B1
• Filed: 01/25/1999
• Issued: 02/24/2004
• Est. Priority Date: 03/15/1996
• Status: Expired due to Fees

• Current Assignee: Wolf Bertling
• Original Assignee: Wolf Bertling
• Inventors: Bertling, Wolf
• Primary Examiner(s): WALLENHORST, MAUREEN
• Application Number:
  US09/142,736
• Time in Patent Office: 1,856 Days
• Field of Search: 422/55, 422/58, 422/68.1, 422/99, 422/102, 422/104, 435/287.2, 435/287.6, 435/288.4, 435/288.7, 204/451
• US Class Current: 422/68.1
• CPC Class Codes: B01L 1/04 Dust-free rooms or enclosures
• CPC Class Codes: B01L 3/502 with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: B01L 7/00 Heating or cooling apparatus autoclaves B01J3/04; Heat insulating devices
• CPC Class Codes: G01N 21/03 Cuvette constructions
• CPC Class Codes: G01N 35/0098 involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation magnetic particles used in immunoassays G01N33/54326; magnetic separation in general B03C

Abstract

The invention relates to a device for analyzing biological or medical specimens, such as nucleic acids, tissue and the like, in which a closure element is provided for the leaktight closure of a preparation chamber formed in a basic body, the preparation chamber being connected to at least one first duct, through which substance can be introduced into and removed from the preparation chamber when the closure element is closed.

Claims

1. A device for analyzing biological or medical specimens, said device comprising:

a body member having a preparation chamber, said preparation chamber defining a bottom surface;

a closure lid hingedly attached to said body member, said closure lid defining said preparation chamber formed in said body member, said closure lid and said body member defining a contact face at a region of contact therebetween when said closure lid is in a closed position;

at least a first and a second duct connected to said preparation chamber, whereby substance can be introduced into and removed from said preparation chamber when said closure lid is in said closed position, said first and second ducts each having one end opening into said preparation chamber, said one end having an inner orifice therein, said first and second ducts further having an opposite end, said opposite end having an outer orifice therein;

said closure lid further comprising a plurality of projecting spacers on the underside thereof for spacing said closure lid a predetermined distance from said bottom surface of said preparation chamber, said plurality of projecting spacers having at least one projecting spacer on which said closure lid, when in said closed position, is supported against said bottom surface of said preparation chamber; and

a peripheral seal disposed at said contact face between said closure lid and said body member.

2. The device according to claim 1 wherein at least a portion of said closure lid is transparent, and further wherein said closure lid is pivotably connected to said body member.

3. The device according to claim 1, wherein at least a portion of said body member is produced from a translucent material.

4. The device according to claim 1, wherein said bottom surface of said body member is produced from a material having a thermal conductivity which is higher than the thermal conductivity of a material from which said closure lid is produced.

5. The device according to claim 4, further comprising means for heating and/or cooling said bottom surface of said preparation chamber.

6. The device according to claim 4, wherein said bottom surface further comprises at least one recess for receiving a magnet.

7. The device according to claim 1, wherein one of said body member and said closure lid has at least one electrode attached thereto.

8. The device according to claim 1, further comprising a gel block located in said preparation chamber, said gel block having a preparation area separated by a permeable barrier.

9. The device according to claim 8, wherein said second duct is located with respect to said first duct such that substance is introduced into and removed from said preparation area when said closure lid is closed.

10. The device according to claim 1, wherein said body member has at least one capacitor plate attached thereto.

11. The device according to claim 10, wherein said at least one capacitor plate comprises two capacitor plates arranged in a mutually opposing arrangement in said body member.