Liquid crystalline polymers
First Claim
1. A composition comprisinga non-mesogenic polymer which exhibits liquid crystalline properties at a temperature below the glass transition temperature of the polymer, wherein a liquid crystalline state is stable at atmospheric conditions and room temperature, and an encapsulated agent.
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Abstract
Methods for inducing a thermoplastic polymer, which can be non-mesogenic, to exhibit liquid crystalline properties have been developed. The method includes the steps of (a) heating the polymer from an initial temperature below its glass transition temperature (Tg) to a temperature greater than its Tg and below its melting temperature (Tm); (b) exposing the polymer to a pressure greater than about 2 metric tons/in2, preferably between about 2 and 10 metric tons/in2, preferably for at least about one minute, while maintaining the temperature greater than its Tg; and (c) cooling the polymer below the Tg while maintaining the elevated pressure. Unlike many prior art transition processes which are reversible, this process provides a liquid crystal state that can be maintained for years at ambient conditions. In a preferred embodiment, the plastics are bioerodible thermoplastic polymers, such as polyanhydrides, some polyesters, polyamides, and polyaromatics. The liquid crystalline polymers can be used in the controlled release or retention of substances encapsulated in the polymers. The polymer can be in a variety of forms including films, film laminants, and microparticles. In a preferred embodiment, the LC polymers are used to encapsulate therapeutic, diagnostic, or prophylactic agents for use in medical or pharmaceutical applications.
41 Citations
13 Claims
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1. A composition comprising
a non-mesogenic polymer which exhibits liquid crystalline properties at a temperature below the glass transition temperature of the polymer, wherein a liquid crystalline state is stable at atmospheric conditions and room temperature, and an encapsulated agent.
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4. A method for release of an encapsulated agent comprising
providing to a release site a composition comprising a) a polymer which exhibits liquid crystalline properties at a temperature below the glass transition temperature of the polymer, wherein a liquid crystalline state is stable at atmospheric conditions and room temperature, and b) an agent encapsulated in the polymer.
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7. An article for the release of an encapsulated agent comprising a polymer which exhibits liquid crystalline properties at a temperature below the glass transition temperature of the polymer and the agent encapsulated in the polymer,
wherein the polymer is in a form selected from the group consisting of films, laminants, coatings, slabs, microparticles, containers for packaging of food or drugs, and orthopedic or prosthetic devices, and wherein a liquid crystalline state is stable at atmospheric conditions and room temperature.
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8. A monolithic composition for controlled delivery of an active agent made using a process comprising
providing a polymer which contains substantially no liquid crystalline phase, heating the polymer above its glass transition temperature and then subjecting the polymer to a pressure sufficient to induce a liquid crystalline phase in at least a portion of the polymer, and combining the polymer with the active agent, wherein the liquid crystalline phase is stable at atmospheric conditions and room temperature.
Specification