Nuclear magnetic resonance analysis of multiple samples
First Claim
1. An NMR apparatus, comprising:
- an NMR transmitter for transmitting one or more signals to a number of samples;
a number of sample holders each operable to receive a corresponding one of the samples for NMR analysis;
a plurality of detection coils each operable to detect a an individual response of a corresponding one of the samples to one or more signals from said NMR transmitter;
an adjustable magnetic field source proximate to a sample space arranged to receive said sample holders, said magnetic field source being operable to selectively provide;
a first magnetic field to generate a first collective response of the samples when received in said sample space and excited by said one or more signals from said NMR transmitter, a second magnetic field having a gradient relative to said first magnetic field to generate a second collective response of the samples when received in said sample space and excited by said one or more signals from said NMR transmitter, said second collective response corresponding to a number of different frequency shifts relative to said first collective response, said different frequency shifts of said second collective response each corresponding to a different one of the samples; and
a processor operable to determine a number of spectral characterizations as a function of said first collective sample response and said second collective sample response, the spectral characterizations each being representative of a different one of the samples.
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Abstract
A Nuclear Magnetic Resonance (NMR) probe device (20) is disclosed. NMR probe device (20) includes a plurality of detection coils (30, 40) each operable to detect a signal from a corresponding one of a plurality of samples (34, 44) undergoing NMR analysis. Also included is a plurality of tuning circuits (31, 41, 38, 48) each coupled to one of detection coils (30, 40) to tune the one of the detection coils (30, 40) to a corresponding resonant frequency for the NMR analysis of the corresponding one of the samples. An electromagnetic shield (22) is positioned between a first one of the detection coils (30, 40) and a second one of the detection coils (30, 40) to isolate the first one of the detection coils (30, 40) and the second one of the detection coils (30, 40) from each other.
108 Citations
22 Claims
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1. An NMR apparatus, comprising:
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an NMR transmitter for transmitting one or more signals to a number of samples;
a number of sample holders each operable to receive a corresponding one of the samples for NMR analysis;
a plurality of detection coils each operable to detect a an individual response of a corresponding one of the samples to one or more signals from said NMR transmitter;
an adjustable magnetic field source proximate to a sample space arranged to receive said sample holders, said magnetic field source being operable to selectively provide;
a first magnetic field to generate a first collective response of the samples when received in said sample space and excited by said one or more signals from said NMR transmitter, a second magnetic field having a gradient relative to said first magnetic field to generate a second collective response of the samples when received in said sample space and excited by said one or more signals from said NMR transmitter, said second collective response corresponding to a number of different frequency shifts relative to said first collective response, said different frequency shifts of said second collective response each corresponding to a different one of the samples; and
a processor operable to determine a number of spectral characterizations as a function of said first collective sample response and said second collective sample response, the spectral characterizations each being representative of a different one of the samples. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An NMR method, comprising:
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operating an NMR spectroscopy system including a sample space, a transmitter, and a plurality of detection coils each disposed about a corresponding one of a plurality of separated samples in the sample space;
generating a first magnetic field in the sample space;
exciting the samples substantially simultaneously with an RF signal during generation of the first magnetic field;
detecting a first collective response of the samples as a result of the first magnetic field and RF excitation;
generating a second magnetic field in the sample space, the second magnetic field including a gradient relative to the first magnetic field;
exciting the samples substantially simultaneously with an RF signal during generation of the second magnetic field;
detecting a second collective response from the samples as a result of the second magnetic field and RF excitation, said second collective response corresponding to a number of different frequency shifts relative to said first collective response, said different frequency shifts of said second collective response each corresponding to a different one of the samples; and
determining a number of spectral characterizations as a function of said first collective sample response and said second collective sample response, the spectral characterizations each being representative of a different one of the samples. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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17. An NMR apparatus, comprising:
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an NMR transmitter for transmitting one or more signals to a number of samples, wherein the number of samples is two or more;
a number of sample holders each operable to receive a corresponding one of the samples for NMR analysis;
a plurality of detection coils electrically connected in parallel, each detection coil operable to detect a response of the corresponding one of the samples to one or more signals from said NMR transmitter;
an adjustable magnetic field source proximate to a sample space arranged to receive said sample holders, said magnetic field source being operable to selectively provide;
a first magnetic field which generates a response from at least a first one of the samples when received in said sample space and excited by an RF signal from said NMR transmitter, a second magnetic field having a gradient relative to said first magnetic field to generate a response from at least a second one of the samples when received in said sample space and excited by an RF signal from said NMR transmitter, wherein the response from the second sample to said second magnetic field corresponds to a frequency shift relative to the response from said second sample that would have occurred as a result of an excitation during the generation of said first magnetic field;
a common receiver connected to each of said detection coils; and
a processor coupled to an output of said common receiver and operable to determine separate spectral characterizations for each response to the first magnetic field and each response to the second magnetic field. - View Dependent Claims (18, 19)
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20. An NMR method, comprising:
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operating an NMR spectroscopy system including a sample space, a transmitter, and a plurality of detection coils each disposed about a corresponding one of a plurality of separated samples in the sample space, wherein said detection coils are electrically connected in parallel and connected to a common receiver;
generating a first magnetic field in the sample space;
applying a first excitation pulse to the sample space;
detecting a response from at least a first one of the samples to the first magnetic field and said first excitation pulse;
generating a second magnetic field in the sample space, the second magnetic field including a gradient relative to the first magnetic field;
applying a second excitation pulse to the sample space;
detecting a response from at least a second one of the samples to the second magnetic field and said second excitation pulse, wherein the response from the second sample to said second magnetic field corresponds to a frequency shift relative to the response from said second sample that would have occurred as a result of an excitation during the generation of said first magnetic field; and
determining a plurality of NMR spectra from the responses, one NMR spectrum corresponding to the response from the first one of the samples to the first magnetic field and first excitation pulse, another NMR spectrum corresponding to the response from the second one of the samples to the second magnetic field and second excitation pulse. - View Dependent Claims (21, 22)
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Specification