Apparatus for the characterization of tissue of epithelial lined viscus

• US 6,697,666 B1
• Filed: 03/06/2000
• Issued: 02/24/2004
• Est. Priority Date: 06/22/1999
• Status: Expired due to Fees

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Richards-Kortum, Rebecca, Utzinger, Urs, Mitchell, Michele Follen
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US09/519,153
• Time in Patent Office: 1,450 Days
• Field of Search: 600/473, 600/475-479, 600/104, 600/156, 600/182, 600/342, 604/27, 604/48
• US Class Current: 600/478
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/4331 of the cervix A61B5/435 takes precedence

Abstract

A method and apparatus for characterizing tissue of epithelial lined viscus in vivo including, for example, the endocervical canal. The method comprises illuminating an interior surface of the viscus with electromagnetic radiation wavelengths to produce a plurality of fluorescence intensity spectra, detecting a plurality of emission wavelengths from the fluorescence intensity spectra, and characterizing the epithelial viscus tissue as a function of the emission wavelengths. The apparatus includes a light source of emitting a plurality of electromagnetic radiation wavelengths, an optical probe connected to the light source, the probe being adapted to apply the plurality of electromagnetic radiation wavelengths to an interior surface of epithelial viscus tissue under test and to gather fluorescence emitted from the tissue, a detector connected to the probe for detecting at least one fluorescence spectrum emitted from the tissue under test and a programmed computer connected to the detector for processing the at least one fluorescence spectrum according to a predetermined algorithm to characterize the tissue under test.

Claims

1. A ring probe for applying a plurality of electromagnetic radiation wavelengths to an interior surface of endocervical canal tissue under test and for gathering fluorescence emitted from the tissue under test, the probe comprising:

a plurality of optical fibers coaxially arranged in a ring shape;

a reflector in operative relationship with the plurality of optical fibers, said reflector adapted to direct light from the probe in a substantially elliptical pattern; and

a flushing channel extending through said probe, said channel adapted to flush the tissue under test.

2. The probe of claim 1, further comprising a first tubing surrounding said plurality of optical fibers, said first tubing being substantially transparent to visible and ultraviolet light.

3. The probe of claim 2, further comprising a second tubing surrounding said first tubing.

4. The probe of claim 1, wherein the reflector comprises a metal plug comprising a polished reflecting surface.

5. The probe of claim 1, wherein the reflector comprises a sapphire tip.

6. The probe of claim 1, wherein the reflector comprises cleaved and polished optical fibers.