Apparatus and method for out-of-hospital thrombolytic therapy

• US 6,699,230 B2
• Filed: 05/07/2001
• Issued: 03/02/2004
• Est. Priority Date: 05/10/2000
• Status: Expired due to Fees

• Current Assignee: Midwest Medical Physics, LLC
• Original Assignee: Minnesota Medical Physics, LLC
• Inventors: Jaafar, Ali, Chornenky, Victor I.
• Primary Examiner(s): Shaver, Kevin
• Assistant Examiner(s): Ramana, Anuradha
• Application Number:
  US09/849,051
• Publication Number:
  US 20020045856A1
• Time in Patent Office: 1,030 Days
• Field of Search: 604/508, 604/151, 604/131
• US Class Current: 604/508
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 2005/1402 Priming
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/3606 cooled
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 39/223 Multiway valves
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/44 having means for cooling or heating the devices or media

Abstract

This invention provides an apparatus and method for emergency administration or self-administration of thrombolytic therapy in early stage of a heart attack. The apparatus includes a needle injector for making a venipuncture, a battery operated micro cooler for maintaining low temperature environment for vials with lyophilized thrombolytic and adjuvant drugs, a container with a diluent for reconstitution of the lyophilized drugs, a programmable infusion pump, and a microprocessor for controlling the process of infusion and recording the data. As the system is activated, said container becomes fluidly communicable with the infusion pump and vials with drugs in the cooler. Designed for autonomous execution of several schedules of infusion, it also can be controlled remotely by a qualified operator via an Internet interface.

Claims

1. A method for providing out-of-hospital thrombolytic therapy for substantially preventing the death of a patient'"'"'s myocardium and early dissolution of a coronary thrombus subsequent to a heart attack, said method comprising:

providing a portable system including;

a library of medication in liquid or lyophilized form including a thrombolytic agent, adjuvant drugs for supportive care during a heart attack and a diluent for reconstitution of drugs;

an intravenous needle providing an access to a patient'"'"'s circulatory system;

a battery operated infusion pump with a set of conduits, on-off and multi-port valves fluidly communicable with the intravenous needle, a source of a diluent, and vials with drugs in the library;

a battery operated micro cooler adapted for keeping the medication library at reduced temperatures for preservation of their potency over a several year period;

a microprocessor based control unit with a stored set of programs, designed to control operation of the infusion pump and valves to provide priming, drug reconstitution, and preprogrammed intravenous infusion of the thrombolytic agent and supportive drugs;

maintaining the system in stand by state continuously until it is needed;

activating the system within thirty minutes after onset of the symptoms of a heart attack;

gaining an intravenous access to the patient'"'"'s circulatory system by puncturing a vein with the intravenous needle provided with the system; and

starting treatment by infusing the thrombolytic agent and adjuvant drugs within thirty minutes after onset of the symptoms of a heart attack.