Methods and apparatus for perfusion of isolated tissue structure
First Claim
1. A method of treatment of a tissue structure in a patient, the tissue structure being coupled to an artery through which blood flows from the patient'"'"'s circulatory system to the tissue structure and to a vein through which blood flows away from the tissue structure to the circulatory system, the method comprising:
- endovascularly positioning a first catheter in the artery;
endovascularly positioning a second catheter in the vein;
occluding the artery around the first catheter;
occluding the vein around the second catheter;
delivering a perfusate comprising a therapeutic agent and an oxygen carrier to the tissue structure through at least one of the first and second catheters while the artery and vein remain occluded, the tissue structure being an organ selected from the group consisting of the brain, at least one breast, at least one lung, at least one kidney, the liver, the spleen, the stomach, the intestines, the pancreas, the colon, the bladder, the thyroid gland, and the prostate;
collecting the perfusate through the other of the at least one of the first and second catheters after the perfusate has perfused at least a portion of the tissue structure;
extracorporeally pumping the perfusate back to the at least one of the first and second catheters; and
extracorporeally oxygenating the oxygen carrier.
2 Assignments
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Accused Products
Abstract
Organs and other tissue structures are isolated and perfused with a therapeutic agent. Isolation is effected by endovascularly positioning catheters having occlusion balloons within the arteries or other blood vessels which supply blood to the organ. Similarly, blood flow from the organ back to the patient'"'"'s circulatory system is blocked by endovascularly positioning one or more catheters carrying occlusion members within the veins or other blood vessels leading from the organ. The therapeutic agent may then be perfused through the organ in either an antegrade or retrograde fashion using the endovascularly positioned catheters while maintaining isolation.
386 Citations
18 Claims
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1. A method of treatment of a tissue structure in a patient, the tissue structure being coupled to an artery through which blood flows from the patient'"'"'s circulatory system to the tissue structure and to a vein through which blood flows away from the tissue structure to the circulatory system, the method comprising:
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endovascularly positioning a first catheter in the artery;
endovascularly positioning a second catheter in the vein;
occluding the artery around the first catheter;
occluding the vein around the second catheter;
delivering a perfusate comprising a therapeutic agent and an oxygen carrier to the tissue structure through at least one of the first and second catheters while the artery and vein remain occluded, the tissue structure being an organ selected from the group consisting of the brain, at least one breast, at least one lung, at least one kidney, the liver, the spleen, the stomach, the intestines, the pancreas, the colon, the bladder, the thyroid gland, and the prostate;
collecting the perfusate through the other of the at least one of the first and second catheters after the perfusate has perfused at least a portion of the tissue structure;
extracorporeally pumping the perfusate back to the at least one of the first and second catheters; and
extracorporeally oxygenating the oxygen carrier. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of treatment of a tissue structure in a patient, the tissue structure being coupled to an artery through which blood flows from the patient'"'"'s circulatory system to the tissue structure and to a vein through which blood flows away from the tissue structure to the circulatory system, the method comprising:
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endovascularly positioning a first catheter in the artery;
endovascularly positioning a second catheter in the vein;
occluding the artery around the first catheter; and
occluding the vein around the second catheter; and
delivering a perfusate to the tissue structure through at least one of the first and second catheters while the artery and vein remain occluded, wherein the tissue structure is a liver, the first catheter occludes a hepatic artery, the second catheter occludes a hepatic vein, and a third catheter occludes a portal vein. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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Specification