Method of determining autoregulatory and perfusion status
First Claim
1. A method of determining the autoregulatory status of a subject, said method comprising the steps of:
- obtaining a measurement of a selected parameter of the retinal blood vessels in a non-stimulated subject;
administering to the subject a preselected stimulus;
obtaining a measurement of the selected parameter of the retinal blood vessels of the subject in response to the administration of the selected stimulus; and
determining the ratio of the measurement for the selected parameter in the non-stimulated retinal blood vessels to the measurement of the selected parameter for the retinal blood vessels following the administration of the selected stimulus whereby the ratio provides an indicator of the autoregulatory function or status of the subject.
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Abstract
A method of determining the autoregulatory status of a subject by obtaining a measurement of a selected parameter of the retinal blood vessels in a non-stimulated subject, administering to the subject a preselected stimulus, obtaining a measurement of the selected parameter of the retinal blood vessels of the subject in response to the administration of the selected stimulus, and determining the ratio of the measurement for the selected parameter in the non-stimulated retinal blood vessels to the measurement of the selected parameter for the retinal blood vessels following the administration of its selected stimulus whereby the ratio provides an indicator of the autoregulatory function or status of the subject.
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Citations
12 Claims
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1. A method of determining the autoregulatory status of a subject, said method comprising the steps of:
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obtaining a measurement of a selected parameter of the retinal blood vessels in a non-stimulated subject;
administering to the subject a preselected stimulus;
obtaining a measurement of the selected parameter of the retinal blood vessels of the subject in response to the administration of the selected stimulus; and
determining the ratio of the measurement for the selected parameter in the non-stimulated retinal blood vessels to the measurement of the selected parameter for the retinal blood vessels following the administration of the selected stimulus whereby the ratio provides an indicator of the autoregulatory function or status of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of diagnosing and monitoring glaucoma in a subject by assessing autoregulatory function, said method comprising the steps of:
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measuring the venous oxygen saturation level of retinal blood vessels of a subject under normoxic conditions;
measuring the venous oxygen saturation level of the retinal blood vessels of the subject under hyperoxic conditions; and
determining the ratio of the normoxic venous oxygen saturation level to the hyperoxic venous oxygen saturation level, wherein the ratio provides an indicator of the autoregulatory or status of the subject which can be used to diagnose and/or monitor the subject for glaucoma. - View Dependent Claims (10, 11)
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12. A method of monitoring blood loss in a subject, said method comprising the steps of:
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measuring of retinal venous oxygen saturation;
measuring retinal venous diameter; and
calculating the ratio of the measurement of retinal venous oxygen saturation to retinal venous diameter wherein the ratio provides an indicator of the amount of blood loss in the subject.
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Specification