Atrial pacing and sensing in cardiac resynchronization therapy

• US 6,701,186 B2
• Filed: 09/13/2001
• Issued: 03/02/2004
• Est. Priority Date: 09/13/2001
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhu, Qingsheng, Spinelli, Julio
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US09/951,699
• Publication Number:
  US 20030050670A1
• Time in Patent Office: 901 Days
• Field of Search: 607/9, 607/15-18, 607/25
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

An implanted heart pacing device includes a right atrium electrode for sensing depolarization from the sino-atrial node when the device determines that the heart should proceed at a natural pulse rate and includes a left atrium electrode for providing an electrical stimulation to the left atrium when the device determines that the heart should not proceed at the natural pulse rate. One or more electrodes may also be located at one or more ventricular walls to provide electrical stimulation to the one or more ventricular walls subsequent to sensing in the right atrium or stimulating in the left atrium to resynchronize the ventricular contraction, such as for compensating for a bundle branch block. Stimulating the left atrium with a left atrium electrode when controlling the pulse rate of the heart allows the left atrium to contract early enough to avoid mitral valve closure resulting from left ventricular contraction.

Claims

1. A method for providing resynchronization therapy to a heart, comprising:

(a) determining whether to allow the heart to proceed at a natural pulse rate;

(b) if it is determined at step (a) that the heart should proceed at a natural pulse rate, then sensing a natural depolarization event with a first electrode in a right atrium, not stimulating the left atrium without monitoring for a depolarization within the left atrium, but subsequently stimulating one or more ventricular walls with at least a second electrode during a cardiac cycle; and

(c) if it is determined at step (a) that the heart should not proceed at a natural pulse rate, then stimulating a left atrium with a third electrode without monitoring for a (depolarization within the left atrium and subsequently stimulating one or more ventricular walls with at least the second electrode during a cardiac cycle.

2. The method of claim 1, wherein the first electrode is positioned at a sino-atrial node.

3. The method of claim 2, wherein step (a) further comprises the step of stimulating the right atrium with the first electrode prior to stimulating the one or more ventricular walls with the second electrode during a cardiac cycle when not allowing the heart to proceed at the natural pulse rate.

4. The method of claim 3, wherein a first interval passes between sensing the natural depolarization event and stimulating the one or more ventricular walls when allowing the heart to proceed at the natural pulse rate, and wherein a second interval different than the first interval passes between stimulating the right atrium and stimulating the one or more ventricular walls when not allowing the heart to proceed at the natural pulse rate.

5. The method of claim 1, wherein the first electrode is positioned at an appendage of the right atrium.

6. The method of claim 5, wherein step (a) further comprises the step of stimulating the right atrium with the first electrode prior to stimulating the one or more ventricular walls with the second electrode during a cardiac cycle when not allowing the heart to proceed at the natural pulse rate.

7. The method of claim 1, wherein the second electrode is positioned in a coronary sinus vein adjacent the left ventricle.

8. The method of claim 1, wherein the third electrode is positioned in a coronary sinus vein adjacent the left atrium.

9. The method of claim 1, wherein the third electrode is positioned within the right atrium and atop the coronary sinus vein.

10. The method of claim 1, wherein the third electrode is positioned on the Bachman'"'"'s bundle.

11. The method of claim 1, wherein the third electrode is positioned at the Triangle of Koch, the method further comprising the step of stimulating the right atrium with the third electrode while stimulating the left atrium.

12. The method of claim 1, wherein step (a) further comprises the steps of:

dynamically setting a pulse rate threshold;

during a cardiac cycle, comparing the natural pulse rate to the pulse rate threshold; and

deciding to not allow the heart to proceed at the natural pulse rate during a subsequent cardiac cycle when the comparison indicates that the natural pulse rate is below the pulse rate threshold.

13. A device for providing resynchronization therapy to a heart, comprising:

a processing module configured to determine whether to allow the heart to proceed at a natural pulse rate;

a first atrium electrode positioned to sense a depolarization in a right atrium;

one or more ventricular electrodes positioned to provide an electrical stimulation to one or more ventricular walls;

a second atrium electrode positioned to provide an electrical stimulation to a left atrium;

a sensing module in communication with the first atrium electrode, the sensing module being configured to sense a depolarization at the first atrium electrode when the processing module determines to allow the heart to proceed at the natural pulse rate; and

a pacing module configured to provide electrical stimulation to the one or more ventricular electrodes subsequent to the sensing module detecting depolarization at the first atrium electrode and not stimulate the second atrium electrode without monitoring for a depolarization within the left atrium when the processing module determines to allow the heart to proceed at the natural pulse rate, the pacing module being further configured to provide electrical stimulation to the second atrium electrode without monitoring for a depolarization within the left atrium and subsequently provide electrical stimulation to the one or more ventricular electrodes when the processing module determines to not allow the heart to proceed at the natural pulse rate.

14. The device of claim 13, wherein the first atrium electrode is positioned at a sino-atrial node.

15. The device of claim 14, wherein the pacing module is further configured to provide electrical stimulation to the first atrium electrode prior to stimulating the one or more ventricular electrodes when the processing module determines to not allow the heart to proceed at the natural pulse rate.

16. The device of claim 15, wherein a first interval passes between the sensing module sensing the depolarization and the pacing module providing electrical stimulation to the one or more ventricular electrodes when the processing module determines to allow the heart to proceed at the natural pulse rate, and wherein a second interval different than the first interval passes between the pacing module providing electrical stimulation to the first atrium electrode and providing electrical stimulation to the one or more ventricular electrodes when the processing module determines to not allow the heart to proceed at the natural pulse rate.

17. The device of claim 13, wherein the first atrium electrode is positioned at an appendage of the right atrium.

18. The device of claim 17, wherein the pacing module is further configured to provide electrical stimulation to the first atrium electrode prior to stimulating the one or more ventricular electrodes when the processing module determines to not allow the heart to proceed at the natural pulse rate.

19. The device of claim 13, wherein at least one of the one or more ventricular electrodes is positioned in a coronary sinus vein adjacent the left ventricle.

20. The device of claim 13, wherein the second atrium electrode is positioned in a coronary sinus vein adjacent the left atrium.

21. The device of claim 13, wherein the second atrium electrode is positioned within the right atrium and atop the coronary sinus vein.

22. The device of claim 13, wherein the second atrium electrode is positioned on the Bachman bundle.

23. The device of claim 13, wherein the second atrium electrode is positioned at the Triangle of Koch.

24. The device of claim 13, wherein the processing module is configured to determine whether to allow the heart to proceed at the natural pulse rate by dynamically setting a pulse rate threshold, comparing the natural pulse rate to the pulse rate threshold, and determining to not allow the heart to proceed at the natural pulse rate when the comparison indicates that the natural pulse rate is below the pulse rate threshold.

25. A device for providing resynchronization therapy to a heart, comprising:

a processing means for determining whether to allow the heart to proceed at a natural pulse rate;

a first atrium electrode means for sensing a depolarization in a right atrium;

one or more ventricular electrode means for providing an electrical stimulation to one or more ventricular walls;

a second atrium electrode means for providing an electrical stimulation to a left atrium;

a sensing means in communication with the first atrium electrode, the sensing means for sensing a depolarization at the first atrium electrode means when the processing means determines to allow the heart to proceed at the natural pulse rate; and

a pacing means for providing electrical stimulation only to the one or more ventricular electrode means subsequent to the sensing means detecting depolarization at the first atrium electrode and not stimulate the second atrium electrode means without monitoring for a depolarization in the left atrium when the processing means determines to allow the heart to proceed at the natural pulse rate, the pacing means being further configured to provide electrical stimulation to the second atrium electrode means without monitoring for a depolarization in the left atrium and subsequently provide electrical stimulation to the one or more ventricular electrode means when the processing means determines to not allow the heart to proceed at the natural pulse rate.

26. The device of claim 25, wherein the first atrium electrode means is positioned at a sino-atrial node.

27. The device of claim 26, wherein the pacing means is further configured to provide electrical stimulation to the first atrium electrode means prior to stimulating the one or more ventricular electrode means when the processing means determines to not allow the heart to proceed at the natural pulse rate.

28. The device of claim 27, wherein a first interval passes between the sensing means sensing the depolarization and the pacing means providing electrical stimulation to the one or more ventricular electrode means when the processing means determines to allow the heart to proceed at the natural pulse rate, and wherein a second interval different than the first interval passes between the pacing means providing electrical stimulation to the first atrium electrode means and providing electrical stimulation to the one or more ventricular electrode means when the processing means determines to not allow the heart to proceed at the natural pulse rate.

29. The device of claim 25, wherein the first atrium electrode means is positioned at an appendage of the right atrium.

30. The device of claim 29, wherein the pacing means is further configured to provide electrical stimulation to the first atrium electrode means prior to stimulating the one or more ventricular electrode means when the processing means determines to not allow the heart to proceed at the natural pulse rate.

31. The device of claim 25, wherein at least one of the one or more ventricular electrode means is positioned in a coronary sinus vein adjacent the left ventricle.

32. The device of claim 25, wherein the second atrium electrode means is positioned in a coronary sinus vein adjacent the left atrium.

33. The device of claim 25, wherein the second atrium electrode means is positioned within the right atrium and atop the coronary sinus vein.

34. The device of claim 25, wherein the second atrium electrode means is positioned on the Bachman bundle.

35. The device of claim 25, wherein the second atrium electrode means is positioned at the Triangle of Koch.

36. The device of claim 25, wherein the processing means is configured to determine whether to allow the heart to proceed at the natural pulse rate by dynamically setting a pulse rate threshold, comparing the natural pulse rate to the pulse rate threshold, and determining to not allow the heart to proceed at the natural pulse rate when the comparison indicates that the natural pulse rate is below the pulse rate threshold.

37. A method for providing resynchronization therapy to a heart, comprising:

(a) determining whether to allow the heart to proceed at a natural pulse rate;

(b) if it is determined at step (a) that the heart should proceed at a natural pulse rate, then sensing a natural depolarization event with a first electrode in a right atrium, not stimulating the left atrium, but subsequently stimulating one or more ventricular walls with at least a second electrode during a cardiac cycle; and

(c) if it is determined at step (a) that the heart should not proceed at a natural pulse rate, then stimulating a left atrium with a third electrode, wherein the third electrode is positioned on the Bachman'"'"'s bundle, and subsequently stimulating one or more ventricular walls with at least the second electrode during a cardiac cycle.

38. A method for providing resynchronization therapy to a heart, comprising:

(a) determining whether to allow the heart to proceed at a natural pulse rate;

(b) if it is determined at step (a) that the heart should proceed at a natural pulse rate, then sensing a natural depolarization event with a first electrode in a right atrium, not stimulating the left atrium, but subsequently stimulating one or more ventricular walls with at least a second electrode during a cardiac cycle; and

(c) if it is determined at step (a) that the heart should not proceed at a natural pulse rate, then stimulating a left atrium with a third electrode, wherein the third electrode is positioned at the Triangle of Koch, the method further comprising the step of stimulating the right atrium with the third electrode while stimulating the left atrium, and subsequently stimulating one or more ventricular walls with at least the second electrode during a cardiac cycle.

39. A method for providing resynchronization therapy to a heart, comprising:

(a) determining whether to allow the heart to proceed at a natural pulse rate, wherein the determination comprises dynamically setting a pulse rate threshold, during a cardiac cycle comparing the natural pulse rate to the pulse rate threshold, and deciding to not allow the heart to proceed at the natural pulse rate during a subsequent cardiac cycle when the comparison indicates that the natural pulse rate is below the pulse rate threshold;

(b) if it is determined at step (a) that the heart should proceed at a natural pulse rate, then sensing a natural depolarization event with a first electrode in a right atrium, not stimulating the left atrium, but subsequently stimulating one or more ventricular walls with at least a second electrode during a cardiac cycle; and

(c) if it is determined at step (a) that the heart should not proceed at a natural pulse rate, then stimulating a left atrium with a third electrode, and subsequently stimulating one or more ventricular walls with at least the second electrode during a cardiac cycle.