Monitoring respiration based on plethysmographic heart rate signal

• US 6,702,752 B2
• Filed: 02/22/2002
• Issued: 03/09/2004
• Est. Priority Date: 02/22/2002
• Status: Active Grant

• Current Assignee: Datex-Ohmeda Incorporated (General Electric Company)
• Original Assignee: Datex-Ohmeda Incorporated (General Electric Company)
• Inventors: Dekker, Andreas Lubbertus Aloysius Johannes
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US10/081,719
• Publication Number:
  US 20030163054A1
• Time in Patent Office: 746 Days
• Field of Search: 600/484, 600/483, 600/481, 600/500, 600/501, 600/502, 600/504, 600/507, 600/508, 600/476, 600/479, 600/480, 600/473, 600/475, 600/529
• US Class Current: 600/484
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

A pleth signal is analyzed to identify a heart rate variability parameter associated with respiration rate. In one embodiment, an associated process involves obtaining a photoplethysmograpic signal, processing the pleth signal to obtain heart rate samples, monitoring the heart rate sample to identify a heart rate variability associated with respiration, and determining a respiration rate based on the heart rate variability. The photoplethysmographic signal may be based on one or more channel signals of a conventional pulse oximeter. The invention thus allows for noninvasive monitoring of respiration rate and expands the functionality of pulse oximeters.

Claims

1. A method for use in monitoring a patient, comprising the steps of:

obtaining a photoplethysmographic (“

pleth”

) signal that is modulated based on interaction of a transmitted optical signal having at least two wavelength cannels with a patient'"'"'s blood;

first processing at least a first portion of said pleth signal to obtain a blood oxygen related value associated with said patient'"'"'s blood;

based on said blood oxygen related value, selecting at least one of said wavelength channels of said pleth signal for additional processing;

second processing at least a second portion of said at least one wavelength channel of said pleth signal to obtain heart rate information regarding a heart rate of said patient; and

third processing said heart rate information to obtain respiration information regarding respiration of said patient.

2. A method as set forth in claim 1, wherein said step of obtaining a pleth signal comprises operating a pulse oximeter to obtain a detector signal corresponding to at least two different wavelength channels of transmitted light.

3. A method as set forth in claim 2, wherein said step of selecting comprises selecting a signal component corresponding to one of said two channels as said pleth signal.

4. A method as set forth in claim 2, wherein said step of selecting comprises selecting signal components corresponding to both of said channels.

5. A method as set forth in claim 1, wherein said step of second processing comprises identifying characteristics of a waveform of said pleth signal corresponding to a pulse cycle of said patient so as to determine one of a period and a frequency of said pulse cycle.

6. A method as set forth in claim 1, wherein said step of second processing comprises performing a spectral analysis of said pleth signal to obtain said heart rate information.

7. A method as set forth in claim 1, wherein said step of second processing comprises using a filter to identify a spectral peak corresponding to said heart rate of the patient.

8. A method as set forth in claim 1, wherein said step of second processing comprises obtaining a heart rate signal reflecting a time series of heart rate values for said patient.

9. A method as set forth in claim 8, wherein said step of third processing comprises identifying a variation in said heart rate signal of said patient associated with said respiration.

10. A method as set forth in claim 1, wherein said step of third processing comprises filtering said heart rate information to identify a variation therein within a frequency range between about 0-1.5 Hz.

11. A method as set forth in claim 10, wherein said variation is within a frequency range between about 0.15 and 0.5 Hz.

12. A method as set forth in claim 10, wherein said variation is within a frequency range between about 0.2-0.4 Hz.

13. A method as set forth in claim 1, further comprising the step of providing an output indicative of a respiration rate of said patient.

23. The method of claim 3, wherein said two channels comprise a red channel and an infrared channel, wherein said step of selecting comprises selecting the red channel if said blood oxygen value is less than about 85%.

14. A method for use in monitoring a patient, comprising the steps of:

obtaining a time-based photoplethysmographic (“

pleth”

) signal that is modulated based on interaction of a transmitted optical signal with a patient'"'"'s blood;

transforming a selected portion of said time-based pleth signal to into a frequency domain pleth signal;

obtaining a heart rate signal, from said frequency domain pleth signal, reflecting a time series of heart rate values for said patient

processing said heart rate signal using at least one filter to distinguish a signal component of interest having a frequency corresponding to a respiration rate of said patient from a potentially interfering signal component; and

providing an output indicative of said respiration rate of said patient based on said signal component of interest.

15. A method as set forth in claim 14, wherein said filter is used to identify a spectral peak in said heart rate signal associated with said respiration rate of said patient.

16. A method as set forth in claim 14, wherein said filter is used to transform said heart rate signal to into a frequency domain respiration signal to identify said respiration rate from said heart rate signal.

24. A method as set forth in claim 14, wherein said step of obtaining a pleth signal comprises operating a pulse oximeter to obtain a detector signal corresponding to at least two different wavelength channels of transmitted light.

25. A method as set forth in claim 24, wherein one of said two different channels is selected for said second processing if said blood oxygen level is within a a predetermined range.

17. An apparatus for use in monitoring a patient, comprising:

a port for receiving a photoplethysmograph (“

pleth”

) signal that is modulated based on interaction of a transmitted optical signal with a patient'"'"'s blood; and

a processor operative for;

first processing said pleth signal to determine a blood oxygen level associated with said patient'"'"'s blood;

based on said blood oxygen level, second processing a selected portion said pleth signal to obtain heart rate information regarding a heart rate of said patient; and

third processing said heart rate information to obtain respiration information regarding respiration of said patient.

18. An apparatus as set forth in claim 17, wherein said apparatus further comprises a source for transmitting an optical signal including at least one wavelength channel relative to a patient, a detector for receiving said transmitted optical signal and a signal processing module for processing a signal from said detector to provide said pleth signal.

19. An apparatus as set forth in claim 18, wherein said processor includes a module for identifying characteristics of a waveform of said pleth signal corresponding to a pulse cycle of said patient so as to determine one of a period and a frequency of said pulse cycle.

20. An apparatus as set forth in claim 17, wherein said processor is operative to perform a spectral analysis of said pleth signal to obtain said heart rate information.

21. An apparatus as set forth in claim 17, wherein said processor includes a filter for identifying a spectral peak corresponding to said heart rate of said patient.

22. An apparatus as set forth in claim 17, wherein said processor is operative for identifying a variation in said heart rate of said patient associated with said respiration.

26. A method for use in monitoring a patient, comprising the steps of:

obtaining a photoplethysmographic (“

pleth”

) signal that is modulated based on interaction of a transmitted optical signal with a patient'"'"'s blood, said pleth signal being in the time domain;

first performing a transform on said time domain pleth signal to obtain spectral information, said spectral information being in the frequency domain;

second performing a transform based on said spectral information to obtain transformed information; and

identifying a physiological parameter of interest based on said transformed information.

27. The method of claim 26, wherein said step of obtaining comprises obtaining a pleth signal having at least two wavelength channels.

28. the method of claim 27, further comprising:

processing said pleth signal to obtain a blood oxygen value associated with said patient'"'"'s blood; and

based on said blood oxygen level, selecting at least one of said wavelength channels of said pleth signal for additional processing.

29. The method of claim 26, further comprising;

prior to said second performing step processing said spectral information to obtain a power pleth spectrum signal.

30. The method of claim 29, wherein said step of processing comprises identifying a spectral peak associated with a heart rate of said patient.

31. The method of claim 30, wherein said step of identifying further comprises generating a time series of heart rate values for said patient.

32. The method of claim 31, wherein said second performing step comprise transforming said time series of heart rate values to obtain respiratory information, said respiratory information being in the frequency domain.

33. The method of claim 32, wherein a spectral peak of said respiratory information in said frequency domain is associated with respiration.

34. A method for use in monitoring a patient, comprising the steps of:

obtaining a time-based photoplethysmographic (“

pleth”

) signal that is modulated based on interaction of a transmitted optical signal having at least two wavelength channels with a patient'"'"'s blood;

first processing an AC component of at least one of said wavelength channels to obtain a heart rate signal reflecting a time series of heart rate values for said patient;

second processing said heart rate information to obtain respiration information regarding respiration of said patient.

35. The method of claim 34, further comprising:

processing at least a first portion of said pleth signal to obtain a blood oxygen related value associated with said patient'"'"'s blood;

and based on said blood oxygen related value, selecting at least one of said wavelength channels of said pleth signal for said first processing step.

36. The method of claim 34, wherein said first processing step includes:

transforming said time-based pleth signal into spectral information;

identifying a spectral peak associated with a heart rate of said patient; and

using a plurality of temporally distinct spectral peaks associated with said heart rate to generate said heart rate signal, wherein said heart rate signal is a time-based signal.

37. The method of claim 34, wherein said second processing step comprises transforming said heart rate signal into a frequency-based signal.

38. The method of claim 37, further comprising identifying a spectral peak in said frequency-based signal associated with a respiration rate of said patient.