Prosthetic heart valve with surface modification

• US 6,702,851 B1
• Filed: 03/18/1998
• Issued: 03/09/2004
• Est. Priority Date: 09/06/1996
• Status: Expired due to Fees

• Current Assignee: Corcym SRL (LivaNova Plc)
• Original Assignee: Sulzer Carbomedics Inc. (Zimmer Biomet Holdings, Inc.)
• Inventors: Chinn, Joseph A., Frautschi, Jack R., Phillips, Richard E.
• Primary Examiner(s): Nguyen, Dinh X.
• Application Number:
  US09/040,914
• Time in Patent Office: 2,183 Days
• Field of Search: 623/2, 623/11, 623/66, 623/901, 623/2.1, 623/2.12, 623/2.2, 623/11.11, 427/2.24, 523/113
• US Class Current: 623/2.1
• CPC Class Codes: A61F 2/2412 with soft flexible valve members, e.g. tissue valves shaped like natural valves check valves with flexible valve members in general F16K15/14
• CPC Class Codes: A61L 2400/02 Treatment of implants to prevent calcification or mineralisation in vivo
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062

Abstract

A biocompatible heart valve is described having incorporated therein an effective amount of applied coating to render the valve resistant to in vivo pathologic thrombus formation and resistant to in vivo pathologic calcification.

Claims

1. A method for reducing calcification and thrombus formation in a biocompatible heart valve comprising a polymer selected from the group consisting of silicone rubbers, polyurethane, and polyetherurethane, said method comprising:

coating, prior to implantation, said heart valve including its leaflets with a coating derived from a compound of the formula;

2. A biocompatible heart valve comprising:

a stent defining a blood flow path; and

a plurality of leaflets comprising a polymer selected from the group consisting of silicone rubber, polyurethane, and polyetherurethane, said leaflets having an applied surface coating effective to render said heart valve resistant to in vivo pathologic thrombus formation and in vivo pathologic calcification, said coating being derived from a compound of the formula

3. A method for reducing calcification and thrombus formation in a biocompatible heart valve comprising a polymer selected from the group consisting of silicone rubbers, polyurethane, and polyetherurethane, said method comprising:

providing a first coat, prior to implantation, to said heart valve including its leaflets, of a first coating derived from a compound of the formula;

4. A biocompatible heart valve comprising:

a stent defining a blood flow path; and

a plurality of leaflets comprising a polymer selected from the group consisting of silicone rubber, polyurethane, and polyetherurethane, said leaflets having an applied surface coating effective to render said heart valve resistant to in vivo pathologic thrombus formation and in vivo pathologic calcification, said applied surface coating comprising;

a first coating derived from a compound of the formula