Membrane for use with implantable devices
First Claim
1. A biointerface membrane for use with an implantable device comprising;
- a) a first domain distal to said implantable device wherein said first domain supports tissue ingrowth and interferes with barrier-cell layer formation and b) a second domain proximal to said implantable device wherein said second domain is resistant to cellular attachment and is impermeable to cells and cell processes.
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Abstract
The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
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Citations
43 Claims
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1. A biointerface membrane for use with an implantable device comprising;
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a) a first domain distal to said implantable device wherein said first domain supports tissue ingrowth and interferes with barrier-cell layer formation and b) a second domain proximal to said implantable device wherein said second domain is resistant to cellular attachment and is impermeable to cells and cell processes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
a) a housing comprising electronic circuitry; and
b) at least one sensor head according to claim 29 operably connected to said electronic circuit means of said housing.
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31. A method of monitoring analyte levels, comprising:
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a) providing i) a host, and ii) an implantable device according to claim 30, and b) implanting said device in said host.
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32. A method according to claim 31, wherein said implanting is subcutaneous.
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33. A method of measuring analyte in a biological fluid, comprising:
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a) providing i) a host, and ii) an implantable device according to claim 30 capable of accurate continuous analyte sensing; and
b) implanting said device in said host.
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34. A method according to claim 33, wherein said implanting is subcutaneous.
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35. An implantable device according to claim 30, wherein said sensor head further comprises a member for determining the amount of glucose in a biological sample.
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36. An analyte measuring device comprising a biointerface membrane according to claim 1.
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37. A cell transplantation device comprising a biointerface membrane according to claim 1.
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38. A drug delivery device comprising a biointerface membrane according to claim 1.
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39. An implantable drug delivery device according to claim 38 wherein said drug delivery device is selected from the group consisting of a pump, a microcapsule and a macrocapsule.
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40. An electrical signal measuring device comprising a biointerface membrane according to claim 1.
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41. An electrical pulse delivering device comprising a biointerface membrane according to claim 1.
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42. A biointerface membrane, wherein said membrane comprises a first domain and a second domain, the membrane comprising the properties of:
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a) promoting tissue ingrowth into said first domain;
b) interfering with barrier cell formation on or within said first domain;
c) resisting barrier cell attachment to said second domain; and
d) blocking cell penetration into said second domain.
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43. A biointerface membrane comprising a first domain and a second domain in combination that are adapted to:
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a) permit tissue ingrowth into said first domain;
b) interfere with barrier cell formation on or within said first domain;
c) resist baffler cell attachment to said second domain; and
d) block cell penetration into said second domain.
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Specification