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Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

  • US 6,703,236 B2
  • Filed: 01/11/2000
  • Issued: 03/09/2004
  • Est. Priority Date: 11/29/1990
  • Status: Expired due to Fees
First Claim
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1. In a combination of thermal cycler capable of performing a polymerase chain reaction comprising a temperature controlled metal block having an array of tapered wells in its top surface, said metal block being capable of receiving a plurality of individual reaction tubes having similarly tapered lower sections and upper sections which project above the top surface of the block when the tubes are placed in said wells, the improvement comprising means for seating said tubes in said wells, said seating means comprising:

  • resiliently deformable sealing caps removably attached to said tubes, a platen, support means for supporting the platen above the block, displacement means associated with the support means for raising the platen above said caps and for lowering it so as to apply a force of at least 30 grams to each cap, and controllable heating means to maintain said platen at a preselected temperature in the range of 94°

    C. to 110°

    C.

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