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Hybrid electrical device with biological components

  • US 6,703,660 B2
  • Filed: 08/22/2001
  • Issued: 03/09/2004
  • Est. Priority Date: 02/22/1999
  • Status: Expired due to Fees
First Claim
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1. An electrical junction between one transistor and at least one voltage-sensitive cell (VSC) characterized by at least one of the following features:

  • (a) voltage transfer between the transistor and the VSC is bi-directional, the transistor being a floating gate depletion type device, the VSC being connected to a floating gate electrode of the transistor and being capable of being stimulated by a voltage pulse applied to the source, channel and drain of the transistor;

    (b) there is no DC bias voltage between the transistor and a biological solution in which the VSC is embedded, the transistor being a depletion type device;

    (c) the VSC is anchored to an external surface of the transistor by binding moieties, optionally through spacers; and

    (d) the voltage transfer between a membrane of the VSC and an external surface of the transistor, and between the external surface of the transistor and the membrane of the VSC is mediated by hyper-polarizable chromophores.

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