Hybrid electrical device with biological components
First Claim
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1. An electrical junction between one transistor and at least one voltage-sensitive cell (VSC) characterized by at least one of the following features:
- (a) voltage transfer between the transistor and the VSC is bi-directional, the transistor being a floating gate depletion type device, the VSC being connected to a floating gate electrode of the transistor and being capable of being stimulated by a voltage pulse applied to the source, channel and drain of the transistor;
(b) there is no DC bias voltage between the transistor and a biological solution in which the VSC is embedded, the transistor being a depletion type device;
(c) the VSC is anchored to an external surface of the transistor by binding moieties, optionally through spacers; and
(d) the voltage transfer between a membrane of the VSC and an external surface of the transistor, and between the external surface of the transistor and the membrane of the VSC is mediated by hyper-polarizable chromophores.
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Abstract
The present invention concerns an electrical junction between one transistor and at least one voltage sensitive cell such as a neuron. The invention further concerns transistors to be used in said junction and methods for their preparation. By another aspect the invention concerns “an artificial chemical synapse” i.e. a junction between a cell, which secretes an agent, and a transistor bearing receptors for the agent, wherein binding of the agent to the receptor changes an electrical property off the transistor.
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Citations
40 Claims
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1. An electrical junction between one transistor and at least one voltage-sensitive cell (VSC) characterized by at least one of the following features:
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(a) voltage transfer between the transistor and the VSC is bi-directional, the transistor being a floating gate depletion type device, the VSC being connected to a floating gate electrode of the transistor and being capable of being stimulated by a voltage pulse applied to the source, channel and drain of the transistor;
(b) there is no DC bias voltage between the transistor and a biological solution in which the VSC is embedded, the transistor being a depletion type device;
(c) the VSC is anchored to an external surface of the transistor by binding moieties, optionally through spacers; and
(d) the voltage transfer between a membrane of the VSC and an external surface of the transistor, and between the external surface of the transistor and the membrane of the VSC is mediated by hyper-polarizable chromophores. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 19, 20, 21, 28, 29)
A is a mono, bi or tricyclic heteroaryl moiety;
Z is a π
-bridging moiety chosen from y=y, wherein y is CH or N;
alkyne, furan, thiophene, pyrole, styrene, phenyl, biphenyl;
D is B—
NR1R2 wherein B is a phenyl, biphenyl or thiophene;
R1 and R2, which may be the same or different, are (CH2)n—
R, R being an amino, hydroxyl or a lower alkyl, or R1 and R2 may be part of a polycyclic heteroaryl system.
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29. A junction according to claim 28, wherein the hyper-polyrizable chromophore is selected from the following:
- azobenzene dyes, stylbene dyes, azomethyne dyes, cyanine, hemicyanine, merocyanine, stylbene, azobenzene, [5-(1-methyl-thiazolidene-2-ylidene) ethylene]-4-oxo-2-thioxo-thiazolidene3-5-(4-dimethyylacid sodium salt (MMT) 5-(4-Dimethylamino-benzylidene)-rodanine (DBR), thiazolidenes and rodanines.
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13. An electrical junction between one transistor and at least one voltage-sensitive cell (VSC) characterized by bi-directional voltage transfer between the transistor and the VSC, the transistor being a floating gate depletion type device, the VSC being associated with a floating gate electrode of the transistor and being capable of being stimulated by a voltage pulse applied to the source, channel and drain of the transistor.
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14. An electrical junction between one transistor and at least one voltage-sensitive cell (VSC) characterized by no DC bias voltage between the transistor and a biological solution in which the VSC is embedded, the transistor being a depletion type device.
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15. A device for selectively detecting voltage changes in a voltage-sensitive cell (VSC) and transferring voltage changes to the VSC, the device comprising:
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an electrical junction between a floating gate depletion type transistor and the VSC, the VSC being connected to a floating gate electrode of the transistor and being capable of being stimulated by a voltage pulse applied to the gate electrode of the floating gate transistor; and
a switching transistor connected by either one of its source and drain electrodes to the gate electrode of said floating gate transistor to apply said voltage pulse by supplying voltage to a gate of the switching transistor. - View Dependent Claims (16, 17, 18)
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- 22. A floating gate transistor to be used in a hybrid device for communicating with a voltage-sensitive cell (VSC), the transistor having an active area defined by a location of an component of the transistor, and having source and drain electrodes making contacts to the active component and a floating gate electrode, the floating gate electrode having its first portion insulated from the active component and accommodated in the vicinity of the active area thereabove, and a second portion accommodated outside said active area and being displaced therefrom in a plane defined by the active component, said second portion defining a site for the VSC accommodation.
- 30. A transistor having its external surface carrying hyper-polarizable chromophores.
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36. An electrochemical junction between an agent-secreting cell and a transistor comprising:
an agent-secreting region of the cell positioned at an orientation enabling transfer of the agent to a location on the surface of the transistor, said location carrying recognition moieties capable of affinity binding to said agents;
said binding between the recognition moiety and the agent causing the modulation of at least one electronic property of the transistor;
said location further comprising catalytic moieties capable of degradation of said agent.- View Dependent Claims (37, 38, 39, 40)
Specification