Doppler guiding catheter using sensed blood turbulence levels

• US 6,704,590 B2
• Filed: 04/05/2002
• Issued: 03/09/2004
• Est. Priority Date: 04/05/2002
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Haldeman, Paul Craig
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US10/117,434
• Publication Number:
  US 20030191392A1
• Time in Patent Office: 704 Days
• Field of Search: 600/433-435, 600/585, 600/455, 600/437, 600/459, 600/461, 600/462, 600/407, 600/479, 600/454, 604/93.01, 604/264, 604/523, 356/336, 738/612.9
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/7415 Sound rendering of measured values, e.g. by pitch or volume variation A61B5/741 takes precedence
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00

Abstract

A guiding catheter includes a Doppler sensor disposed at a distal end of a flexible shaft. The Doppler sensor can sense a blood flow turbulence level within a chamber of the heart or a blood vessel of the heart. Detecting changes in a blood flow turbulence level is used to assist guiding of the distal end of the flexible shaft. The Doppler sensor may include a piezoelectric sensor or an optical sensor. The sensor readings may be processed to show turbulence through a time domain or frequency domain presentation of velocity. The sensor readings can be used to modulate an audible waveform to indicate turbulence. The guiding catheter may further include steering apparatus enabling deflection of the distal tip.

Claims

1. A guiding catheter used for locating a patient'"'"'s circulatory structure, comprising:

a flexible shaft having an open lumen dimensioned for receiving a payload; and

a detector comprising a Doppler sensor disposed at a distal end of the flexible shaft, the Doppler sensor sensing blood flow velocity within the patient'"'"'s circulatory structure accessed by the distal end of the flexible shaft, the detector producing blood flow turbulence information indicative of a transition between laminar blood flow and turbulent blood flow, wherein the transition between laminar and turbulent blood flow is indicative of a relative change in position of the flexible shaft'"'"'s distal end between cardiac vessel and cardiac chamber locations.

2. The guiding catheter according to claim 1, wherein the Doppler sensor is arranged to sense a radial and an axial turbulence component, the detector performing a comparison of the radial and axial turbulence components to produce the blood flow turbulence information.

3. The guiding catheter according to claim 1, wherein the sensed blood flow velocity is transformed to a frequency response indicative of blood flow turbulence.

4. The guiding catheter according to claim 1, wherein the Doppler sensor is mounted at the distal end of the flexible shaft to have a radially directed field of view.

5. The guiding catheter according to claim 1, wherein the Doppler sensor comprises an emitter and a receiver.

6. The guiding catheter according to claim 5, wherein the emitter of the Doppler sensor comprises an ultrasonic piezoelectric crystal, and the receiver of the Doppler sensor comprises an ultrasonic piezoelectric crystal.

7. The guiding catheter according to claim 5, wherein the emitter of the Doppler sensor comprises a laser light source, and the receiver of the Doppler sensor comprises an optical lens.

8. The guiding catheter according to claim 1, further comprising a steering mechanism connected to a distal section of the flexible shaft enabling selectable deflection of the distal end of the flexible shaft.

9. The guiding catheter according to claim 8, wherein the steering mechanism comprises a steering tendon connected to the distal section of the flexible shaft, the steering tendon longitudinally disposed along the flexible shaft and accessible from a proximal end of the shaft.

10. The guiding catheter according to claim 1, wherein the flexible shaft has an outer diameter ranging from about 8 French to about 10 French.

11. The guiding catheter according to claim 1, wherein the open lumen is adapted to receive an implantable cardiac lead.

12. The guiding catheter according to claim 1, wherein the open lumen is adapted to receive an injection of fluid.

13. A method for cannulating a destination blood vessel, comprising:

introducing the distal end of a guiding catheter comprising a flexible shaft and a Doppler sensor disposed at a distal end of the flexible shaft into a patients access vessel;

distally advancing the guiding catheter through a circulatory pathway which includes at least a portion of a heart chamber;

monitoring blood flow turbulence readings from the Doppler sensor of the guiding catheter and detecting a transition between turbulent and laminar blood flow using the blood flow turbulence readings; and

guiding the distal tip of the guiding catheter based at least in part on the detected transition between turbulent and laminar blood flow to locate the destination blood vessel.

14. The method according to claim 13, wherein monitoring blood flow turbulence readings further comprises deriving a radial and an axial turbulence component from the blood flow turbulence readings, the radial and axial turbulence components used to detect the transition between turbulent and laminar blood flow.

15. The method according to claim 13, wherein monitoring blood flow turbulence comprises measuring a frequency response of blood flow velocity.

16. The method according to claim 13, wherein monitoring blood flow turbulence readings from the Doppler sensor further comprises using pulse Doppler.

17. The method according to claim 13, wherein monitoring blood flow turbulence readings from the Doppler sensor further comprises using continuous wave Doppler.

18. The method according to claim 13, wherein monitoring blood flow turbulence further comprises using an audio signal to detect blood flow turbulence levels.

19. The method according to claim 13, further comprising cannulating the destination blood vessel with the distal end of the guiding catheter after locating the destination blood vessel.

20. The method according to claim 19, further comprising inserting a payload through the guiding catheter into the destination blood vessel after cannulating the destination blood vessel.

21. The method according to claim 20, wherein the payload comprises a cardiac pacing lead.

22. The method according to claim 20, wherein the payload comprises an injection of fluid.

23. The method according to claim 13, wherein the destination blood vessel includes the coronary sinus of the patient'"'"'s heart.

24. The method according to claim 23, wherein the circulatory pathway includes the right atrium of the patient'"'"'s heart accessed via the superior vena cava.

25. A system for locating and cannulating a patient'"'"'s circulatory structure, comprising:

a catheter comprising;

a flexible shaft having an open lumen dimensioned to receive a payload;

a Doppler sensor disposed at a distal end of the flexible shaft, the Doppler sensor sensing blood flow velocity within a patient'"'"'s circulatory structure accessed by the distal end of the flexible shaft;

a communication medium coupled with the Doppler sensor, the communication medium transmitting the sensed blood flow velocity to a proximal end of the flexible shaft; and

a processing device coupled to the communication medium, the processing device processing the sensed blood flow velocity to produce turbulence level information indicative of a transition between turbulent blood flow and laminar blood flow.

26. The system according to claim 25, wherein the Doppler sensor is arranged to sense a radial and an axial blood flow velocity component, and wherein the processing device processes the radial and axial velocity components to produce the turbulence level information.

27. The system according to claim 25, wherein the processing device transforms the sensed blood flow velocity to a frequency response.

28. The system according to claim 25, wherein the Doppler sensor is mounted at the distal end of the flexible shaft to provide a radially directed field of view.

29. The system according to claim 25, wherein the Doppler sensor comprises an emitter and a receiver.

30. The system according to claim 29, wherein the emitter of the Doppler sensor comprises an ultrasonic piezoelectric crystal, the receiver of the Doppler sensor comprises an ultrasonic piezoelectric crystal, and the communication medium comprises at least one electrical conductor.

31. The system according to claim 29, wherein the emitter of the Doppler sensor comprises a laser light source, the receiver of the Doppler sensor comprises an optical lens, and the communication medium comprises at least one optical fiber.

32. The system according to claim 25, further comprising a steering mechanism connected to a distal section of the flexible shaft enabling selectable deflection of the distal end of the flexible shaft.

33. The system according to claim 32, wherein the steering mechanism comprises a steering tendon connected to the distal section of the flexible shaft, the steering tendon longitudinally disposed along the flexible shaft and accessible from a proximal end of the shaft.

34. The system according to claim 25, wherein the flexible shaft has an outer diameter ranging from about 8 French to about 10 French.

35. The system according to claim 25, wherein the open lumen is adapted to receive an implantable cardiac lead.

36. The system according to claim 25, wherein the open lumen is adapted to receive an injection of fluid.