Technique for quantiating biological markers using quantum resonance interferometry

• US 6,704,662 B2
• Filed: 07/02/2002
• Issued: 03/09/2004
• Est. Priority Date: 02/22/1999
• Status: Expired due to Term

• Current Assignee: ViaLogy LLC (Yourgene Health Plc)
• Original Assignee: Vialogy Corp.
• Inventors: Gulati, Sandeep
• Primary Examiner(s): Horlick, Kenneth R.
• Assistant Examiner(s): KIM, YOUNG J
• Application Number:
  US10/189,885
• Publication Number:
  US 20030044775A1
• Time in Patent Office: 616 Days
• Field of Search: 435/6, 435/91.1, 435/91.2, 702/27, 422/82.05, 712/200
• US Class Current: 702/27
• CPC Class Codes: G16B 25/00 ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
• CPC Class Codes: G16B 25/10 Gene or protein expression profiling; Expression-ratio estimation or normalisation

Abstract

A technique is described for quantitating biological indicators, such as viral load, using interferometric interactions such as quantum resonance interferometry. A biological sample is applied to an array information structure that has a plurality of elements that emit data indicative of viral load. A digitized output pattern of the arrayed information structure is interferometrically enhanced by generating interference between the output pattern and a reference wave. The interferometrically enhanced output pattern is then analyzed to identify emitted data indicative of viral load which in turn is used to determine viral load.

Claims

1. A technique for determining viral load within a patient sample applied to an arrayed information structure, where the arrayed information structure has a plurality of elements that emit data indicative of viral load, based on digitized output patterns from the arrayed information structure, comprising the steps of:

interferometrically enhancing the output patterns to cause interference between the output patterns and a reference wave; and

analyzing the interferometrically enhanced output patterns to identify data indicative of viral load to determine viral load.

2. The technique of claim 1 wherein the interferometric enhancement comprises the step of:

inducing resonances based on interference between an expressor function and spectral characteristics of the output patterns; and

wherein the analysis step comprises the step of detecting the resonances, if any, at each element in the interferometrically enhanced output patterns from the arrayed information structure.

3. The technique of claim 2 wherein the interferometric enhancement further includes the step tessellating the interferometrically enhanced output patterns prior to the induction of resonances.

4. The technique of claim 2 wherein and expressor function is a chosen from a group comprising:

stochastic expressor functions, quantum expressor functions.

5. The technique of claim 2 wherein the spectral characteristics are selected from a group comprising:

noise, signal, and noise coupled to signal.

6. The technique of claim 2 further including the initial steps of generating a set of nonlinear expressor functions by:

calculating values representative of a pre-selected Hamiltonian function;

calculating harmonic amplitudes for the Hamiltonian function;

generating an order function from the Hamiltonian;

function measuring entrainment states of the order function; and

modulating the order function using the entrainment states to yield the expressor function.

7. The technique of claim 2 wherein the arrayed information structure is a microarray.

8. The technique of claim 1 wherein the arrayed information structure embodies measurements selected from a group comprising:

intensity, amplitude, and phase.

9. The technique of claim 1 wherein the analysis step comprises the step of mapping the interferometrically enhanced output pattern to coordinates on a viral diffusion curve.

10. The technique of claim 9 wherein the mapped coordinates are non-linearly filtered.

11. A system for determining viral load within a digitized image of a biological sample measurement taken from a microarray comprising:

an interferometric unit configured to generate an interference between the digitized image and a reference wave to enhance the digitized image; and

an analysis unit for analyzing the interferometrically enhanced digitized image to determine viral load.

12. The system of claim 11, wherein said interferometric unit is configured to induce resonances based on interference between an expressor function and spectral characteristics of the digitized image.

13. The system of claim 12, wherein said analysis unit is configured to detect resonances, if any, within the interferometrically enhanced digitized image that are associated with viral load.

14. The system of claim 12 wherein and expresser function is chosen from a group comprising:

stochastic expresser functions, quantum expressor functions.

15. The system of claim 11 wherein said interferometric unit tessellates the digitized image of the output pattern prior to generating an interference between the digitized image and a reference wave.

16. The system of claim 11 wherein the digitized image embodies measurements from a group comprising:

intensity, amplitude, phase.

17. The system of claim 11 wherein the analysis unit maps the interferometrically enhanced digitized image to a viral diffusion curve.

18. The system of claim 11 wherein the analysis unit maps the interferometrically enhanced digitized image to a viral diffusion curve using fractal filtering.

19. A system for determining the level of a biological indicator within a patient sample applied to an arrayed information structure, where the arrayed information structure emits data indicative of the biological indicator, based on digitized images of the arrayed information structure, comprising:

signal processing means for generating interference between the digitized image and a reference wave to enhance the digitized image; and

analysis means for analyzing the enhanced digitized image to determine the level of the biological indicator.

20. A system for determining the level of a biological indicator within a patient sample applied to an arrayed information structure, where the arrayed information structure emits data indicative of the biological indicator, based on digitized output patterns from the arrayed information structure, comprising:

an interferometric unit configured to generate an interference between the digitized image and a reference wave to enhance the digitized output pattern; and

an analysis unit for analyzing the interferometrically enhanced digitized output pattern to determine the level of the biological indicator.

21. A system for determining the level of a biological indicator within a patient sample applied to an arrayed information structure, where the arrayed information structure emits data indicative of the biological indicator, based on digitized output patterns from the arrayed information structure, comprising:

an interferometric unit configured to generate an interference between the digitized output pattern and a reference wave to enhance the digitized output pattern; and

an analysis unit for analyzing the interferometrically enhanced digitized output pattern to determine the level of the biological indicator.