Invasive therapeutic probe

• US 6,706,040 B2
• Filed: 11/23/2001
• Issued: 03/16/2004
• Est. Priority Date: 11/23/2001
• Status: Active Grant

• Current Assignee: Medlennium Technologies Incorporated
• Original Assignee: Medlennium Technologies Incorporated
• Inventors: Chiu, John, Mahon, John, Shishegar, Ahmad, Rheinish, Scott
• Primary Examiner(s): Leubecker, John P.
• Assistant Examiner(s): Vrettakos, Peter J
• Application Number:
  US09/992,490
• Publication Number:
  US 20030100894A1
• Time in Patent Office: 844 Days
• Field of Search: 128/898, 606/32, 606/34, 606/37, 606/38, 606/39-42, 606/45, 606/33, 606/27-29, 606/30, 607/96, 607/98, 607/99, 607/101, 607/102, 607/105, 607/113
• US Class Current: 606/41
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2018/00083 low, i.e. electrically insulating
• CPC Class Codes: A61B 2018/00148 with metal
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00702 Power or energy
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/183 characterised by the type of antenna

Abstract

An invasive therapeutic probe assembly and related methods for application of RF energy to a volume of body tissue are provided. The probe assembly includes an RF source configured to provide an RF energy having selected characteristics, a probe having a probe shaft and an antenna positioned therein, and a feed line for providing conductivity from the RF source to the antenna probe. The probe assembly is adapted to generate a zone of therapeutic effectiveness having a selected geometry and volume. The related method includes positioning the probe in a selected location with reference to a target tissue, initiating an electromagnetic field from the antenna having a selected geometry, and producing a zone of therapeutic effectiveness having a selected geometry and volume. The producing step preferably includes, taking periodic temperature measurements from sensors positioned at a selected location, and manipulating the selected characteristics of the RF energy to include duration and/or power level.

Claims

1. An invasive probe assembly for therapeutic treatment, the probe assembly comprising:

a coaxial feed line having an inner conductor, an outer conductor, and an insulating sleeve axially surrounding the outer conductor, the feed line configured for electrical contact to an RF source configured to provide RF energy having selected characteristics including a prescribed operating frequency; and

a probe having a rigid probe shaft and an antenna positioned therein, the antenna including

a first dipole region at a distal end of the probe shaft and connected to the inner conductor of the feed line, the first dipole region having a rounded metallic tip,

a second dipole region proximally spaced therefrom, forming a dipole axis, the second dipole region having

a radiating skirt electricalliy connected at a distal end to the outer conductor of the feed line and therefrom axially spaced from the outer conductor to a proximal end the skirt, and

a cylindrical insulator disposed between the outer conductor and the skirt, thereby forming a choke at the prescribed operating frequency;

wherein the length of the choke is substantially a quarter wavelength as determined for propagation of the provided energy through the cylindrical insulator, and

a structural spacer formed of dielectric material disposed between the dipole regions along the dipole axis.

2. An invasive probe assembly as defined in claim 1, wherein the skirt and cylindrical insulator are a unitary piece in which the skirt is a metallic coating disposed on a first end and on an outer side surface of the cylindrical insulator.

3. An invasive probe assembly as defined in claim 2, wherein:

the insulating sleeve of the feed line terminates prior to the cylindrical insulator, and

the metallic coating is further disposed in an axial bore defined by the cylindrical insulator.

4. An invasive probe assembly as defined in claim 1, wherein the dielectric spacer is formed of polycarbonate and defines an axial bore sized to allow the inner conductor to extend therethrough.

5. An invasive probe assembly as defined in claim 1, wherein the cylindrical insulator has a dielectric constant between about 9 and 10 and the prescribed operating frequency is about 2.45 GHz.

6. An invasive probe assembly as defined in claim 5, wherein the choke has a length of about 1 cm.

7. An invasive probe assembly for therapeutic treatment, the probe assembly comprising:

a coaxial feed line having an inner conductor, an outer conductor and an insulating sleeve axially surrounding the outer conductor, the feed line configured for electrical contact to an RF source configured to provide RF energy having selected characteristics including a prescribed operating frequency; and

a probe having a rigid probe shaft with an antenna positioned therein, the antenna including,

a first dipole region located at a distal end of the probe shaft and connected to the inner conductor of the feed line,

a second dipole region proximally spaced therefrom, forming a dipole axis, the second dipole region having

a radiating skirt electrically connected at a distal end to the outer conductor of the feed line and therefrom axially spaced from the outer conductor to a proximal end the skirt, and

a cylindrical insulator disposed between the outer conductor and the skirt, thereby forming a choke at the prescribed operating frequency;

wherein the length of the choke is substantially a quarter wavelength as determined for propagation of the provided energy through the cylindrical insulator, and

a structural spacer formed of dielectric material disposed between the dipole regions along the dipole axis, the spacer defining an axial bore allowing the inner conductor to extend therethrough.

8. A probe assembly as defined in claim 7, wherein the center conductor is hollow and optical strands are positioned therein.

9. A probe assembly as defined in claim 8, wherein a selected number of the optical strands are allocated for optical temperature sensing.

10. A probe assembly as defined in claim 8, wherein a selected number of the optical strands allocated for imaging.

11. An invasive probe assembly as defined in claim 7, wherein the skirt is a portion of the outer conductor folded back over the cylindrical insulator.

12. An invasive probe assembly as defined in claim 11, wherein the first dipole region is a metallic cap having a rounded tip tapering to a cylindrical portion.

13. An invasive probe assembly as defined in claim 12, wherein the cylindrical portion of the cap defines a rearwardly facing recess and the structural spacer includes a portion disposed within the recess.

14. An invasive probe assembly as defined in claim 13, wherein the skirt and cylindrical insulator are a unitary piece in which the skirt is a metallic coating disposed on a first end and an outer side surface of the cylindrical insulator.

15. An invasive probe assembly as defined in claim 14, wherein:

the insulating sleeve of the feed line terminates prior to the cylindrical insulator, and

the metallic coating is disposed in an axial bore defined by the cylindrical insulator.

16. An invasive probe assembly as defined in claim 7, wherein the cylindrical insulator is formed of ceramic.

17. An invasive probe assembly as defined in claim 16, wherein the choke has a length of about 1 cm.

18. A method of heating body tissue, the method comprising:

positioning a probe in a selected location with reference to a target tissue, the probe having an antenna therein that receives RF energy from an RF source, the antenna including first and second dipole regions forming a dipole axis and a structural spacer formed of dielectric material disposed between the dipole regions along the dipole axis;

wherein the first dipole region has a rounded metallic tip, a second dipole region has a radiating skirt and a cylindrical insulator thereby forming a choke having a length substantially a quarter wavelength as determined for propagation of the provided energy through the cylindrical insulator;

initiating an electric field from the antenna having a selected geometry; and

producing a zone of therapeutic effectiveness having a selected geometry and volume.

19. A method as defined in claim 18, wherein the producing step further includes taking periodic temperature measurements from sensors positioned at a selected location, and manipulating selected characteristics of the RF energy to include duration and/or power level.

20. A method of making an invasive probe having a dipole antenna and a feed line adapted to connect the dipole antenna to an RF source, the method comprising:

providing a first dipole region formed of an insulator having a cylindrical shape with a predetermined thickness and length, and having a conductive material coated thereon such that the insulator is substantially covered with conductive material and the proximal end of the insulator is void of conductive material;

fitting the coated insulator at a selected location along the feed line such that it is in contact with an outer conductor of the feed line thereby forming a choke;

placing a structural spacer of dielectric material forward of the first dipole region such that an inner connector of the feed extends through an axial bore thereof; and

placing a second dipole region forward of the structural spacer and in electrical contact with the inner conductor.

21. A method as defined in claim 20, wherein the insulator is ceramic.

22. A method as defined in claim 20, further including the step of selecting dimensions and materials for the antenna to effectuate a zone of therapeutic effectiveness having a selected geometry and volume.

23. A method as defined in claim 20, wherein the providing step further includes the steps of coating all surfaces of the insulator with conductive material to a selected thickness, and cutting the coated insulator to a selected length, and thereby providing the insulator with a proximal end void of conductive material.