Chemical sensor and use thereof
First Claim
1. A sensor, based on a dynamic initial change measuring process, for detecting an analyte in a solution, the sensor comprising:
- a working electrode;
a selective membrane having first and second sides, the working electrode and the first side being spaced apart from each other to form a flow-through chamber therebetween;
an inlet to the chamber;
an outlet from the chamber;
a source of buffer;
a source of recognition element;
an injector connected to each of said sources for selecting the buffer or the recognition element;
a pump connected to injector for pumping the selected one of the buffer and the recognition element through the inlet, the chamber and the outlet;
the second side being in contact with the solution so that analyte passes through the membrane and reacts with the recognition element, and the working electrode generating a dynamic initial change signal proportional to the concentration of the analyte.
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Abstract
A chemical sensor selectively detects an analyte in a solution. The sensor comprises a flow-through chamber, a selective membrane, a transducer, an inlet for a liquid flow containing a recognition element, and an outlet. To detect an analyte in a solution, a recognition element is contacted with the solution containing the analyte via a selective membrane. This results in a response detectable by a transducer. The recognition element is injected into a flow, and the flow is passed into a flow-through chamber comprising the transducer and the selective membrane, where it contacts the analyte passing from the solution outside the chamber. The recognition element and the analyte interact to provide a signal that is detected by the transducer. The chemical sensor is used for detecting analyte(s) in a reactor system, a flow system or in an in vivo system.
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Citations
6 Claims
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1. A sensor, based on a dynamic initial change measuring process, for detecting an analyte in a solution, the sensor comprising:
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a working electrode;
a selective membrane having first and second sides, the working electrode and the first side being spaced apart from each other to form a flow-through chamber therebetween;
an inlet to the chamber;
an outlet from the chamber;
a source of buffer;
a source of recognition element;
an injector connected to each of said sources for selecting the buffer or the recognition element;
a pump connected to injector for pumping the selected one of the buffer and the recognition element through the inlet, the chamber and the outlet;
the second side being in contact with the solution so that analyte passes through the membrane and reacts with the recognition element, and the working electrode generating a dynamic initial change signal proportional to the concentration of the analyte. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification