Composition for implantation into the human and animal body

• US 6,706,273 B1
• Filed: 04/13/2001
• Issued: 03/16/2004
• Est. Priority Date: 08/14/1999
• Status: Expired due to Fees

• Current Assignee: Ivoclar Vivadent AG
• Original Assignee: Ivoclar Vivadent AG
• Inventors: Roessler, Ralf
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Pulliam, Amy E.
• Application Number:
  US09/807,569
• Time in Patent Office: 1,068 Days
• Field of Search: 424/422, 424/423, 424/426
• US Class Current: 424/422
• CPC Class Codes: A61K 6/69 Medicaments
• CPC Class Codes: A61K 6/838 Phosphorus compounds, e.g. apatite
• CPC Class Codes: A61K 6/864 Phosphate cements apatite A61K6/838
• CPC Class Codes: A61K 6/891 Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/0063 Phosphorus containing materials, e.g. apatite
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/10 Ceramics or glasses
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

Compositions for implantation into the human and animal body as bone replacement contain inter alia calcium and phosphorus and consist in particular of mixtures of powders and admixing liquids. They are suitable for preparing calcium phosphate cement pastes which cure at room and/or body temperature. The reaction systems contain a powdery base mixture comprising CaKPO₄, Ca₂NaK(PO₄)₂ and Ca(H₂PO₄)₂.H₂O.

Claims

1. Implantable composition which comprises a base mixture of 80 to 65 wt.-% of the combination of

(a) CaKPO₄ and

(b) Ca₂NaK(PO₄)₂ and 20 to 35 wt.-% of

(c) Ca(H₂PO₄)₂.H₂O.

2. Composition according to claim 1, in which, relative to the overall quantity of CaKPO₄ and CaNaK(PO₄)₂, the proportion by weight of CaKPO₄ lies between 1% and 99% and that of CaNaK(PO₄)₂ between 99% and 1%.

3. Composition according to claim 1, in which the base mixture is present in the form of a powder mixture.

4. Composition according to claim 1, which in addition comprises at least one of the following components:

CaHPO₄.H₂O, CaCO₃, CaSO₄, CaSO₄.O.5H₂O, CaSO₄2H₂O,

CaHPO₄, nanoparticular hydroxylapatite.

5. Composition according to claim 1, which comprises a powder mixture of the base mixture with addition of CaHPO₄.H₂O and CaCO₃ and wherein, relative to the powder mixture, the proportion by weight of CaHPO₄.H₂O lies between 1% and 30% and the proportion by weight of CaCO₃ between 30% and 1%.

6. Composition according to claim 1, which comprises a powder mixture of the base mixture with addition of CaHPO₄.H₂O and wherein, relative to the powder mixture, the proportion by weight of CaHPO₄.H₂O lies between 1% and 60%.

7. Composition according to claim 1, which comprises a powder mixture of the base mixture with addition of CaCO₃ and wherein, relative to the powder mixture, the proportion by weight of CaCO₃ lies between 1% and 60%.

8. Composition according to claim 1, which also comprises at least one of the following components:

mannose-6-phosphate, saccharose-octasulphate, saccharose-octasulphate in the form of the sodium or potassium complex salt, an antibiotic and a disinfectant.

9. Composition according to claim 1, which also comprises an admixing liquid.

10. Composition according to claim 9, in which the admixing liquid contains water.

11. Composition according to claim 9, which is present in the form of a paste.

12. Composition according to claim 9, in which the admixing liquid comprises an aqueous solution of mannose-6-phosphate, of saccharose-octasulphate or of a mixture of these.

13. Composition according to claim 9, in which the admixing liquid comprises an aqueous solution of Na₂HPO₄.

14. Composition according to claim 9, in which the admixing liquid comprises at least one of the following components

mannose-6-phosphate, saccharose-octasulphate, saccharose-octasulphate in the form of the sodium or potassium complex salt, an antibiotic and a disinfectant.

15. Composition according to claim 1, which also comprises biologically active proteins.

16. Composition according to claim 15, which comprises, as biologically active proteins, growth factors, bone morphogenetic proteins, enamel amelogenins and/or elastase inhibitors.

17. A method for the repair or replacement of bones, teeth or parts thereof comprising applying a composition according to claim 1 to a bone, tooth or parts thereof in need of repair.

18. The method according to claim 17, which the composition is applied to the selected substrate in the form of a paste, moulded and cured.