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IR-MALDI mass spectrometry of nucleic acids using liquid matrices

  • US 6,706,530 B2
  • Filed: 05/10/1999
  • Issued: 03/16/2004
  • Est. Priority Date: 05/07/1998
  • Status: Expired due to Fees
First Claim
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1. A method for detecting the presence or absence of a nucleic acid in a sample, comprising:

  • (a) mixing the nucleic acid with a liquid matrix;

    (b) analyzing the mixture using infrared matrix-assisted laser desorption/ionization mass spectrometry;

    (c) detecting the nucleic acid by determining the mass of the nucleic acid by a mass spectrometric format for separation and detection of desorbed and ionized molecules, wherein;

    the nucleic acid is detected if present in the sample;

    the nucleic acid comprises at least 280 nucleotides; and

    the accuracy for determining the mass of the nucleic acid is within about 1%.

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