Brachytherapy needle with impedance measurement apparatus and methods of use

• US 6,709,380 B2
• Filed: 05/31/2001
• Issued: 03/23/2004
• Est. Priority Date: 05/31/2001
• Status: Expired due to Fees

• Current Assignee: Neose Technologies, Inc.
• Original Assignee: Neose Technologies, Inc.
• Inventors: Seiler, Keith, Green, Thomas C., Hogendijk, Michael, DeSoto, Larry, Ziring, Edo
• Primary Examiner(s): Jeffery, John A.
• Application Number:
  US09/873,666
• Publication Number:
  US 20020183582A1
• Time in Patent Office: 1,027 Days
• Field of Search: 600/3, 600/7, 600/547, 606/41, 606/46, 604/272, 604/264
• US Class Current: 600/3
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

Apparatus and methods for depositing radioactive seeds into a patient'"'"'s prostate are provided that include impedance measuring circuitry for detecting whether the distal end of an elongated needle extends into a patient'"'"'s bladder. The elongated needle includes two conductive traces and a lumen adapted to receive a column of radioactive seeds and spacers. The impedance measuring circuitry is coupled to the conductive traces of the elongated needle and provides a display indicative of the monitored impedance.

Claims

1. A method for depositing radioactive seeds into a patient'"'"'s prostate in the vicinity of the patient'"'"'s bladder, the method comprising:

providing a device comprising a needle having proximal and distal ends, and a lumen extending therebetween and adapted to accept a column of radioactive seeds and spacers, and means for detecting whether the distal end of the needle projects into the patient'"'"'s bladder;

inserting the needle through the patient'"'"'s prostate until the means for detecting indicates that the distal end is disposed in the bladder;

withdrawing the needle proximally until the means for detecting indicates that the distal end is no longer disposed in the bladder; and

operating the needle to deposit the column of radioactive seeds and spacers into the patient'"'"'s prostate.

2. The method of claim 1 wherein the device further comprises a single-use needle and a reusable handle, the method further comprising removably coupling the needle to the handle.

3. The method of claim 1 wherein the means for detecting comprises circuitry for measuring tissue impedance, the method further comprising continuously measuring tissue impedance during the steps of inserting the needle and withdrawing the needle.

4. The method of claim 3 wherein the means for detecting comprises a light meter, the method further comprising illuminating the light meter responsive to the measured impedance.

5. The method of claim 1 wherein the device further comprises a plunger disposed within the lumen in contact with a proximal end of the column of radioactive seeds and spacers, and operating the needle comprises maintaining the plunger stationary while retracting the needle proximally.

6. A method for treating prostate cancer comprising:

providing a needle having a lumen, proximal and distal ends, first and second conductive traces, and means for detecting a tissue boundary coupled to the first and second conductive traces;

inserting the needle into a patient'"'"'s prostate;

measuring an impedance of tissue disposed between the first and second conductive traces using the means for detecting a tissue boundary;

monitoring the impedance measured by the means for detecting a tissue boundary to determine when the distal end penetrates a boundary between the patient'"'"'s prostate and an adjacent mucosa of the patient; and

withdrawing the needle from the mucosa so that the distal end is disposed fully within the patient'"'"'s prostate.