Apparatus and method for monitoring respiration with a pulse oximeter

• US 6,709,402 B2
• Filed: 02/22/2002
• Issued: 03/23/2004
• Est. Priority Date: 02/22/2002
• Status: Expired due to Term

• Current Assignee: Datex-Ohmeda Incorporated (GE Healthcare Technologies, Inc.)
• Original Assignee: Datex-Ohmeda Incorporated (GE Healthcare Technologies, Inc.)
• Inventors: Dekker, Andreas Lubbertus Aloysius Johannes
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/081,168
• Publication Number:
  US 20030163033A1
• Time in Patent Office: 760 Days
• Field of Search: 600/310, 600/322, 600/323, 600/324, 600/325, 600/330, 600/336, 600/529
• US Class Current: 600/529
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips

Abstract

An apparatus and method for monitoring a secondary physiological process through variations caused by the secondary process in an optical signal used to calculate values related to blood oxygen levels. In particular, the optical signal may be divided into distinct portions such that a portion more directly affected by a particular secondary physiological process may be isolated and the secondary physiological process monitored. The apparatus and method is particularly useful for photoplethysmographically monitoring a patient'"'"'s respiration frequency through changes in relative concentrations of blood oxygen related values that are proportionally related to the amounts of venous and arterial blood in a portion of tissue.

Claims

1. A method for monitoring a patient'"'"'s respiration through changes in the patient'"'"'s blood concentrations, said method comprising the steps of:

monitoring a portion of perfused tissue to obtain at least one plethysmographic signal;

processing said at least one plethysmographic signal to obtain pulsatile AC signal component information and substantially non-pulsatile DC signal component information, wherein said non-pulsatile DC signal component information reflects a variability separate from a pulse of a patient;

determining a relative concentration of arterial blood and venous blood in said tissue based on said DC signal component information; and

monitoring said relative concentration of arterial and venous blood based on said DC signal component information over time to determine a respiration frequency from increases and decreases in said relative concentration.

2. The method of claim 1, wherein said step of monitoring said relative concentration of venous and arterial blood is performed non-invasively.

3. The method of claim 2, wherein said step of non-invasively monitoring is performed photoplethysmographically.

4. The method of claim 3, wherein said step of photoplethysmographically monitoring further comprises the steps of:

applying electromagnetic radiation of at least two wavelengths to said portion of tissue;

detecting signals for each said wavelength applied to said portion of tissue; and

obtaining said substantially non-pulsatile DC signal component information for each of said at least two wavelengths.

5. The method of claim 1, wherein said step of determining a relative concentration further comprises:

determining a first quantitative value associated with arterial blood in said tissue; and

determining a second quantitative value associated with venous blood in said tissue.

6. The method of claim 5, wherein said first quantitative value is associated with oxygenated hemoglobin (HbO₂) and said second quantitative value is associated with de-oxygenated hemoglobin (Hb).

7. The method of claim, 6 wherein said relative concentration is a ratio HbO₂/Hb of said oxygenated hemoglobin and said de-oxygenated hemoglobin.

8. The method of claim 7 wherein said ratio is calculated using the following:

$\frac{{\mathrm{HbO}}_2}{\mathrm{Hb}}=\frac{{\mathrm{\varepsilon <br><br>}}_{1<br><br>\mathrm{Hb}}-R<br><br>\text{\hspace{1em}<br><br>}<br><br>{\mathrm{\varepsilon <br><br>}}_{2<br><br>\mathrm{Hb}}}{R<br><br>\text{\hspace{1em}<br><br>}<br><br>{\mathrm{\varepsilon <br><br>}}_{2<br><br>\mathrm{HbO2}}-{\mathrm{\varepsilon <br><br>}}_{1<br><br>\mathrm{HbO2}}}$

wherein, ε

_1Hb and ε

_2Hb represent extinction coefficients of said de-oxygenated hemoglobin for a first and second wavelengths of said signal plethysmographic, respectively, and ε

_1HbO2 and ε

_2HbO2 represent extinction coefficients of said oxygenated hemoglobin for said first and second wavelengths of said plethysmographic signal, respectively, and R represent the ratio of ration for said plethysmographic signal.

9. The method of claim 1, wherein said relative concentration is monitored for said variations over a frequency range of 0 to 1.5 hertz.

22. The method of claim, 7 wherein said relative concentration is a ratio, HbO₂/Hb, of said of oxygenated hemoglobin and said de-oxygenated hemoglobin.

10. An apparatus for monitoring respiration, using optical signals to identify changes in values related to blood oxygen levels caused by said respiration, said apparatus comprising:

at least a first emitter for controllably emitting at least first and second wavelengths of electromagnetic radiation to a portion of living tissue;

a detector for detecting signals relative to said emitted first and second wavelengths of said electromagnetic radiation and producing a detector signal indicative thereof; and

a processor operable to receive said detector signal, said processor further operable for;

processing said detector signal to obtain pulsatile AC signal component information and substantially invariant DC signal component information; and

using said DC signal component information to determine a quantitative value related to a ratio of arterial blood to venous blood of said tissue, wherein said non-pulsatile DC signal component information reflects a variability separate from a pulse of a patient;

monitoring said value to determine variations in said ratio over a predetermined frequency range indicative of respiration; and

generating an output signal indicative of respiration.

11. The apparatus of claim 10, wherein said at least a first emitter comprises at least a first light emitting diode.

12. The apparatus of claim 11, further comprising a first and second light emitting diode for emitting electromagnetic radiation in the visible and infrared range respectively.

13. The apparatus of claim 10, wherein said processor monitors said value over a predetermined time cycle for changes in said value indicative of respiration.

14. The apparatus of claim 13, wherein said predetermined time cycle is from 0 to 1.5 hz.

15. The apparatus of claim 10, wherein said quantitative value includes a first value associated with oxygenated hemoglobin (HbO₂) and a second value associated with de-oxygenated hemoglobin (Hb).

16. The apparatus of claim 10, wherein said ratio is calculated using the following:

$\frac{{\mathrm{HbO}}_2}{\mathrm{Hb}}=\frac{{\mathrm{\varepsilon <br><br>}}_{1<br><br>\mathrm{Hb}}-R<br><br>\text{\hspace{1em}<br><br>}<br><br>{\mathrm{\varepsilon <br><br>}}_{2<br><br>\mathrm{Hb}}}{R<br><br>\text{\hspace{1em}<br><br>}<br><br>{\mathrm{\varepsilon <br><br>}}_{2<br><br>\mathrm{HbO2}}-{\mathrm{\varepsilon <br><br>}}_{1<br><br>\mathrm{HbO2}}}$

wherein, ε

_1Hb and ε

_2Hb represent extinction coefficients of said de-oxygenated hemoglobin for a first and second wavelengths of said plethysmographic signal, respectively, and ε

_1HbO2 and ε

_2HbO2 represent extinction coefficients of said oxygenated hemoglobin for said first and second wavelengths of said plethysmographic signal, respectively, and R represent the ratio of ration for said plethysmographic signal.

17. A method for monitoring a patient'"'"'s respiration through changes in the patient'"'"'s blood concentrations, said method comprising the steps of:

applying first and second optical signals to a portion of tissue, wherein said first and second optical signals have different wavelengths;

detecting said first and second optical signals as modulated by said tissue and generating a detector signal representative of said first and second optical signals;

processing said detector signal to obtain first and second DC signal components corresponding with said first and second optical signals;

determining a relative concentration of arterial and venous blood in said tissue based on said first and second DC signal components; and

monitoring said relative concentration to identify a variation associated with respiration.

18. The method of claim 17, wherein monitoring comprises monitoring said relative concentration over a predetermined time cycle to identify said variation.

19. The apparatus of claim 18, wherein said predetermined time cycle is from 0 to 1.5 hz.

20. The method of claim 17, wherein said step of determining a relative concentration further comprises:

determining a first quantitative value associated with arterial blood in said tissue; and

determining a second quantitative value associated with venous blood in said tissue.

21. The method of claim 20, wherein said first quantitative value is associated with oxygenated hemoglobin (HbO₂) and said second quantitative value is associated with de-oxygenated hemoglobin (Hb).