Vascular inducing implants

• US 6,709,425 B2
• Filed: 01/31/2001
• Issued: 03/23/2004
• Est. Priority Date: 09/30/1998
• Status: Expired due to Fees

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Weiser, Michael F., Forcucci, Stephen J., Forde, Sean, Choh, Richard T., Gambale, Richard A.
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US09/774,319
• Publication Number:
  US 20010004690A1
• Time in Patent Office: 1,147 Days
• Field of Search: 604/526, 604/890.1, 604/891.1, 604/500, 604/93.01, 604/22, 604/507, 604/508, 604/511, 604/285, 607/119, 607/120, 623/1.1, 623/1.42, 623/1.45, 128/898, 128/897
• US Class Current: 604/500
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61F 2/94 Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

Claims

1. A method of promoting angiogenesis in ischemic tissue comprising the steps of:

providing an implant,

associating an angiogenic substance with the implant,

accessing the ischemic tissue,

inserting the implant into the tissue,

orienting the implant in the tissue to place the tissue in stress by expanding the implant from a low profile first configuration to a large profile second configuration.

2. A method of promoting angiogenesis as defined in claim 1 comprising the further step of associating a angiogenic substance with the device after it is implanted.

3. A method of promoting angiogenesis as defined in claim 1 wherein the implant comprises a body having an interior containing an angiogenic substance to promote angiogenesis.

4. A method of promoting angiogenesis in ischemic tissue as defined in claim 1 further comprising:

irritating the tissue sufficiently to cause an injury response in the tissue that includes thrombosis and initiates angiogenesis.

5. A method of promoting angiogenesis as defined in claim 4 wherein the tissue irritation is caused by the presence of a implant in the tissue.

6. A method as defined in claim 5 wherein the implants are implanted entirely and only within the myocardium.

7. A method of promoting angiogenesis as defined in claim 5 wherein the tissue is myocardial tissue.