Meningococcal antigens

• US 6,709,660 B1
• Filed: 04/30/1999
• Issued: 03/23/2004
• Est. Priority Date: 01/14/1998
• Status: Expired due to Fees

• Current Assignee: Novartis Ag
• Original Assignee: Chrion SRL
• Inventors: Rappuoli, Rino, Pizza, Mariagrazia, Grandi, Guido, Masignani, Vega, Scarlato, Vincenzo
• Primary Examiner(s): Graser, Jennifer E.
• Application Number:
  US09/302,626
• Time in Patent Office: 1,789 Days
• Field of Search: 424/250.1, 424/234.1, 424/185.1, 424/190.1, 424/249.1, 530/300, 530/350
• US Class Current: 424/250.1
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C07K 14/22 from Neisseriaceae (F)

Abstract

The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.

Claims

1. An isolated or recombinant protein comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:

2, 4, and 6.

2. An isolated or recombinant protein comprising an immunogenic fragment having 60% or greater sequence identity to the contiguous sequence of amino acids depicted in SEQ ID NOS:

2, 4, or 6.

3. A composition comprising a protein of claim 1 or 2.

4. A diagnostic composition comprising a protein of claim 1 or 2.

5. A pharmaceutical composition according to claim 3.

6. An isolated or recombinant protein of claim 2, where in the protein has 80% or greater sequence identity to the contiguous sequence of amino acids depicted in SEQ ID NOS:

2, 4, or 6.

7. An isolated or recombinant protein of claim 2, wherein the protein has 90% or greater sequence identity to the contiguous sequence of amino acids depicted in SEQ ID NOS:

2, 4, or 6.

8. An isolated or recombinant protein of claim 2, wherein the protein has 95% or greater sequence identity to the contiguous sequence of amino acids depicted in SEQ ID NOS:

2, 4, or 6.

9. A pharmaceutical composition according to claim 4.