Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
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Abstract
Disubstituted bicyclic heterocycles of general formula I
Compounds of general formula I, wherein E is an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E is a cyano group, are valuable intermediates for preparing the other compounds of general formula I.
23 Citations
21 Claims
- 1. A compound of the formula I:
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11. 3-Methyl-2-[(4-amidinophenyl)thiomethyl]imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide, or a tautomer or salt thereof.
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12. 3-Methyl-2-[N-(4-amidinophenyl)aminomethyl]imidazo[4,5-b]-pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide, or a tautomer or salt thereof.
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13. 3-Methyl-2-[(4-amidinophenyl)thiomethyl]imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-hydroxycarbonylethyl)amide, or a tautomer or salt thereof.
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14. 3-Methyl-2-[N-(4-amidinophenyl)aminomethyl]imidazo[4,5-b]-pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-hydroxycarbonylethyl)amide, or a tautomer or salt thereof.
Specification