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Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics

  • US 6,710,226 B1
  • Filed: 11/27/2000
  • Issued: 03/23/2004
  • Est. Priority Date: 12/02/1997
  • Status: Expired due to Term
First Claim
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1. A method of screening an antibody to Aβ

  • for use in treatment of Alzheimer'"'"'s disease, comprising;

    administering an antibody that specifically binds to Aβ

    to a transgenic mouse whose genome comprising a DNA sequence expressing an APP, wherein the mouse is disposed to develop characteristics of Alzheimer'"'"'s disease;

    detecting a reduction in the extent or rate of development of at least one of the characteristic of Alzheimer'"'"'s disease relative to a control mouse.

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