Breath-based diagnostic device including an array of multiple sensors

• US 6,712,770 B2
• Filed: 05/23/2002
• Issued: 03/30/2004
• Est. Priority Date: 05/23/2001
• Status: Active Grant

• Current Assignee: Industrial Technology Research Institute
• Original Assignee: Industrial Technology Research Institute
• Inventors: Lin, Yuh-Jiuan, Guo, Hong-Ru
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US10/154,365
• Publication Number:
  US 20030060726A1
• Time in Patent Office: 677 Days
• Field of Search: 600/529, 600/531, 600/532, 73/233
• US Class Current: 600/532
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/20 for measuring urological functions restricted to the evaluation of the urinary system A61B5/4375 takes precedence
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

A breath-based diagnostic device. The device includes an array of multiple gas sensors, a database storage device and a microprocessor. The gas sensors contain material capable of reacting with volatile organic chemicals in the exhaled breath of the subject. The database storage device stores established responses to a variety of disease. The microprocessor compares the response detected by the gas sensors and the database so as to perform the diagnosis.

Claims

1. A breath-based diagnostic device comprising:

(a) a multi-sensor array comprising a plurality of sensory devices each reacting with specific volatile organic vapor in breath to generate a signal, wherein each of the sensory devices reacts with the volatile organic vapor directly and/or through a sensory receptor coated on the sensory device;

(b) a database storage device for information storage;

(c) a signal processing unit comprising a oscillator coupled to each of the sensory devices, a frequency counter coupled to the oscillator for counting oscillation frequency, and a digital/analog recorder for recording digital/analog data; and

(d) a microprocessor for receiving a signal generated by the multi-sensor array and comparing the signal with information stored in the database.

2. The diagnostic device as set forth in claim 1, further comprising a breath collecting device.

3. The diagnostic device as set forth in claim 1, further comprising a display unit for displaying the information in the database and the comparison result generated by the microprocessor.

4. The diagnostic device as set forth in claim 1, wherein the multiple-array sensor is a quartz crystal sensor.

5. The diagnostic device as set forth in claim 4, wherein the quartz crystal sensor is a piezoelectric quartz crystal sensor.

6. The diagnostic device as set forth in claim 1, wherein the multiple-array sensor is a metal oxide semiconductor sensor.

7. The diagnostic device as set forth in claim 1, wherein the multiple-array sensor is a surface acoustic wave device.

8. The diagnostic device as set forth in claim 1, wherein the multiple-array sensor is an electrode device.

9. The diagnostic device as set forth in claim 1, wherein the multiple-array sensor is a fiber optic device.

10. The diagnostic device as set forth in claim 1, wherein the sensory receptor is a conductive polymer, organic compound, organelle, peptide, protein, antibody, nucleic acid, metal oxide or metal.

11. The diagnostic device as set forth in claim 1, wherein the signal generated from the multi-array is a pattern signal.

12. The diagnostic device as set forth in claim 11, wherein the pattern signal is a fingerprint, block chart, wave chart, or radio diagram.

13. The diagnostic device as set forth in claim 1, wherein the signal generated from the multi-array is a digital signal.

14. The diagnostic device as set forth in claim 1, wherein the diagnostic device is used for the diagnosis of uremia, cirrhosis, hyper methionine disorder, ketoacidosis, diabetes, periodontosis, gingivitis, lung cancer, pulmonary abscess, schizophrenia, or intestinal obstruction.

15. The diagnostic device as set forth in claim 1, wherein the diagnostic device is used for the diagnosis of disorders relating to abnormal metabolism.

16. A breath-based method for disorder diagnosis, comprising the following steps:

collecting a breath sample from a subject to be diagnosed;

reacting the breath sample with a breath-based diagnostic device comprising;

(a) a multi-sensor array comprising a plurality of sensory devices each reacting with specific volatile organic vapor in breath to generate a signal, wherein each of the sensory devices reacts with the volatile organic vapor directly and/or through a sensory receptor coated on the sensory device;

(b) a database storage device for information storage;

(c) a signal processing unit comprising a oscillator coupled to each of the sensory devices, a frequency counter coupled to the oscillator for counting oscillation frequency, and a digital/analog recorder for recording digital/analog data; and

(d) a microprocessor for receiving a signal generated by the multi-sensor array and comparing the signal with information stored in the database to generate a signal;

comparing the signal with information in the database to determine the physiological state of the subject.

17. The breath-based method as set forth in claim 16, wherein the database comprises information for a variety of disorders in the form of a pattern and/or digital record.

18. The breath-based method as set forth in claim 16, wherein the method is used for the diagnosis of uremia, cirrhosis, hyper methionine disorder, ketoacidosis, diabetes, periodontosis, gingivitis, lung cancer, pulmonary abscess, schizophrenia, or intestinal obstruction.

19. The breath-based method as set forth in claim 18, wherein the method is used for the diagnosis of uremia or cirrhosis.