Partial aortic occlusion devices and methods for cerebral perfusion augmentation

• US 6,712,806 B2
• Filed: 11/07/2002
• Issued: 03/30/2004
• Est. Priority Date: 03/01/1999
• Status: Expired due to Term

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Coaxis Incorporated (Trimble Inc.)
• Inventors: St. Germain, Jon P., Barbut, Denise R.
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Thompson, Michael M
• Application Number:
  US10/291,150
• Publication Number:
  US 20030097036A1
• Time in Patent Office: 509 Days
• Field of Search: 604/22, 604/48, 604/96.01, 604/98.01, 604/500, 604/505-507, 604/509, 604/532, 604/101-1-1, 604/103, 604/103.03, 604/104, 604/164.1, 604/164.01, 604/164.05, 604/158, 604/236, 604/264, 604/914, 604/915, 604/919, 606/159, 606/192, 606/194, 606/198, 606/200, 600/17, 600/18, 600/465, 600/470, 128/898
• US Class Current: 604/509
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/1204 temporary occlusion
• CPC Class Codes: A61B 17/12045 double occlusion, e.g. during anastomosis
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 2017/22054 with two balloons
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61F 2002/068 Modifying the blood flow model, e.g. by diffuser or deflector
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61M 2025/0002 with a pressure sensor at the distal end
• CPC Class Codes: A61M 2025/0034 characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores making of catheters A61M25/0009
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow general flow characteristics A61M2206/10
• CPC Class Codes: A61M 2025/0081 Soft tip
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2210/127 : Aorta
• CPC Class Codes: A61M 2230/005 : Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/30 : Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 25/00 : Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/003 : characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves catheter tips A61M25/0067
• CPC Class Codes: A61M 25/0032 : characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
• CPC Class Codes: A61M 25/0068 : Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0069 : Tip not integral with tube
• CPC Class Codes: A61M 25/0074 : Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/008 : Strength or flexibility characteristics of the catheter tip
• CPC Class Codes: A61M 25/0082 : Catheter tip comprising a tool
• CPC Class Codes: A61M 25/0147 : with movable mechanical means, e.g. pull wires
• CPC Class Codes: A61M 25/0662 : Guide tubes
• CPC Class Codes: A61M 25/1011 : Multiple balloon catheters

Abstract

A method for increasing cerebral blood flow is described. A catheter is inserted into the descending aorta, the catheter having a proximal region, a distal region, and at least one expandable member mounted on the distal region. The expandable member is positioned downstream from the takeoff of the brachiocephalic artery. The expandable member is expanded to at least partially obstruct blood flow in the aorta. The expandable member is then cycled between greater and lesser obstruction of blood flow. In this manner, renal ischemia and lower limb ischemia is avoided.

Claims

1. A method for increasing cerebral blood flow, comprising the steps of:

inserting a catheter into the descending aorta, the catheter having a proximal region, a distal region, and at least one expandable member mounted on the distal region;

locating the at least one expandable member downstream from the takeoff of the brachiocephalic artery;

expanding the at least one expandable member to at least partially obstruct blood flow in the aorta during systole and diastole; and

cycling the at least one expandable member between greater and lesser obstruction of blood flow.

2. The method of claim 1, wherein the step of cycling the at least one expandable member is synchronized with the cardiac cycle.

3. The method of claim 1, wherein the step of cycling the at least one expandable member is independent of the cardiac cycle.

4. The method of claim 1, wherein the step of cycling the at least one expandable member produces a change in blood flow around the at least one expandable member to 80% of baseline during systole and to 20% of baseline during diastole.

5. The method of claim 1, wherein the step of cycling the at least one expandable member produces a change in blood flow around the at least one expandable member to 70% of baseline during systole and to 30% of baseline during diastole.

6. The method of claim 1, wherein the step of cycling the at least one expandable member produces a change in blood flow around the at least one expandable member to 80% of baseline for six cardiac cycles and to 20% of baseline for two cycles.

7. The method of claim 1, wherein the step of cycling the at least one expandable member produces a change in blood flow around the at least one expandable member to 70% of baseline for five cardiac cycles and to 10% of baseline for one cardiac cycle.

8. The method of claim 1, wherein the at least one expandable member is initially expanded to achieve 70% obstruction of blood flow in the aorta, and then is cycled between 60% and 80% obstruction of blood flow in the aorta.

9. The method of claim 1, further comprising the steps of measuring a physiologic parameter and adjusting the expansion of the at least one expandable member based on the measured physiologic parameter.

10. The method of claim 1, wherein the at least one expandable member comprises one balloon.

11. The method of claim 1, wherein the at least one expandable member comprises two balloons.