Porous tissue scaffolds for the repair and regeneration of dermal tissue

• US 6,712,850 B2
• Filed: 11/30/2001
• Issued: 03/30/2004
• Est. Priority Date: 11/30/2001
• Status: Expired due to Term

• Current Assignee: Endo-Surgery, Inc.
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Gosiewska, Anna, Vyakarnam, Murty Narayan, Zimmerman, Mark Charles
• Primary Examiner(s): Isabella, David J.
• Assistant Examiner(s): Chattopadhyay, Urmi
• Application Number:
  US10/016,808
• Publication Number:
  US 20030105525A1
• Time in Patent Office: 851 Days
• Field of Search: 424/422-426, 623/924-926, 623/11.11, 623/66.1, 623/15-1-, 623/23.72, 623/23-5-, 523/113-114, 606/230
• US Class Current: 623/15.12
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: Y10S 623/924 Material characteristic
• CPC Class Codes: Y10S 623/925 Natural
• CPC Class Codes: Y10S 623/926 Synthetic

Abstract

The present invention is a synthetic, biocompatible, bioabsorbable, porous foam tissue scaffolds possessing physicochemical properties suitable for use in the repair and regeneration of dermal tissue and to methods of preparing the foam scaffold.

Claims

1. A synthetic, biocompatible, bioabsorbable foam scaffold suitable for use in the repair and/or regeneration of dermal tissue in a body of a patient:

comprising,

a synthetic, biocompatible, bioabsorbable, aliphatic, elastomeric copolymer comprising copolymerized ε

-caprolactone and glycolide at a molar ratio of ε

-caprolactone;

glycolide ranging from about 30;

70 to about 40;

60, wherein said scaffold is about 0.25 mm to about 0.75 mm thick and has porosity of 90 percent or greater.

2. The foam scaffold of claim 1 wherein said foam scaffold is about 0.4 mm to about 0.6 mm thick and has porosity from 90 percent to 97 percent.

3. The foam scaffold of claim 1 wherein the copolymer comprises about 35 mole percent ε

-caprolactone copolymerized with about 65 mole percent glycolide.

4. The foam scaffold of claim 3 wherein the scaffold is about 0.5 mm thick and has porosity of about 93 percent.

5. The foam scaffold of claim 1 wherein said scaffold is adapted to be substantially absorbed by the body within about 120 days of implantion.

6. The foam scaffold of claim 1 wherein said foam scaffold is adapted to be completely absorbed by the body within about 90 days of implantion.

7. The foam scaffold of claim 1 wherein about 50 percent of said thickness of said foam scaffold is adapted to be infiltrated by granulation tissue within about 10 days of implantation.

8. The foam scaffold of claim 1 wherein about 75 percent of said thickness of said foam scaffold is adapted to be infiltrated by granulation tissue within about 7 days of implantation.

9. The foam scaffold of claim 1 wherein said foam scaffold is adapted to be substantially submerged in or enveloped by granulation tissue within about 28 days of implantation.

10. The foam scaffold of claim 1 wherein said foam scaffold is adapted to be completely submerged in or enveloped by granulation tissue within about 28 days of implantation.