Methods for increasing vascularization and promoting wound healing
First Claim
1. A method for promoting wound healing, comprising administering an effective amount of a matrix to a wound, the matrix consisting essentially of a mixture of gelatin, dextran or sulfated dextran at least one polar amino acid, and optionally, one or more of intact collagen, an-L-arginine analogue, L-cysteine, and a divalent chelator.
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Abstract
The present invention provides a method of stimulating vascularization at a site in a mammal, said method comprising contacting said site with a matrix comprising gelatin and a nitric oxide inhibitor. The gelatin is preferably denatured collagen. The nitric oxide inhibitor may be a sulfonated moiety. The inhibitor may be an L-arginine analog, such as aminoguanidine, N-monoethyl L-arginine, N-nitro-L-arginine and D-arginine. The matrix may further comprise a nitric oxide scavenger, such as dextran, heparin, cysteine and cystine.
57 Citations
34 Claims
- 1. A method for promoting wound healing, comprising administering an effective amount of a matrix to a wound, the matrix consisting essentially of a mixture of gelatin, dextran or sulfated dextran at least one polar amino acid, and optionally, one or more of intact collagen, an-L-arginine analogue, L-cysteine, and a divalent chelator.
- 25. A method for promoting wound healing, comprising administering an effective amount of a matrix to a wound, the matrix comprising a mixture of denatured collagen, dextran or sulfated dextran, aminoguanidine, and an effective amount of polar amino acids selected from the group consisting of arginine, lysine, histidine, glutamic acid, aspartic acid, and mixtures thereof.
Specification