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Ocular therapeutic agent delivery devices and methods for making and using such devices

  • US 6,713,081 B2
  • Filed: 03/15/2001
  • Issued: 03/30/2004
  • Est. Priority Date: 03/15/2001
  • Status: Expired due to Term
First Claim
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1. An ocular implant providing sustained-release of a first therapeutic agent to the eye for a prolonged period of time, comprising:

  • a composite material matrix layer including;

    (i) a first therapeutic agent, (ii) a polymeric matrix material into which the first therapeutic agent is dispersed, including (1) a bioerodible polymer permeable to the therapeutic agent, the permeable polymer being superhydrolyzed polyvinyl alcohol, and (2) a water-soluble polymer having greater water solubility than the permeable polymer, the water-soluble polymer being a cellulose ether polymer, and (iii) a discrete solid core containing the first or a second therapeutic agent, the therapeutic agent being dispersed, and the solid core being embedded within the composite material matrix layer.

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