Enhancement of peptide cellular uptake
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Abstract
Peptide conjugates of the formula are provided
wherein:
n is from 1 to 10;
X is
(a) C═O, when the R—X group is attached to:
(i) the N-terminus of the peptide, or
(ii) a side chain of the peptide where the functional group of the side chain to which the R—X group is attached is NH2 or OH; or
(b) O or NH, when the R—X group is attached to
(i) the C-terminus of the peptide, or
(ii) a side chain of the peptide where the functional group of the side chain to which the R—X group is attached is COOH or CONH2; and
R is selected from the group consisting of C2-18 alkyl; C2-18 alkoxy; C2-14 alkylenyl containing one or two double bonds; cyclobutyl; cyclopentyl; cyclohexyl optionally monosubstituted with a C1-5 straight or branched chain alkyl group; phenyl optionally monosubstituted with a C1-5 straight or branched chain alkyl group; and benzyl.
86 Citations
11 Claims
- 1. A peptide conjugate of the formula I
Specification