Molecularly-imprinted material made by template-directed synthesis

• US 6,713,416 B2
• Filed: 01/08/2003
• Issued: 03/30/2004
• Est. Priority Date: 07/30/1999
• Status: Expired due to Fees

• Current Assignee: the united states of america as represented by the secretary of the navy
• Original Assignee: the united states of america as represented by the secretary of the navy
• Inventors: Dordick, Jonathan S., Turner, David C., Clark, Douglas S., Ratna, Banahalli R., Schoen, Paul E., Kust, Paul R., Markowitz, Michael A., Gaber, Bruce P.
• Primary Examiner(s): Nutter, Nathan M.
• Application Number:
  US10/337,723
• Publication Number:
  US 20030139483A1
• Time in Patent Office: 447 Days
• Field of Search: 501/12, 501/32, 501/80
• US Class Current: 501/12
• CPC Class Codes: B01J 37/00 Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C01B 37/02 Crystalline silica-polymorphs, e.g. silicalites dealuminated aluminosilicate zeolites
• CPC Class Codes: C01P 2004/52 highly monodisperse size distribution
• CPC Class Codes: C01P 2004/62 Submicrometer sized, i.e. from 0.1-1 micrometer
• CPC Class Codes: C01P 2004/64 Nanometer sized, i.e. from 1-100 nanometer
• CPC Class Codes: C01P 2006/16 Pore diameter
• CPC Class Codes: C09C 1/3081 Treatment with organo-silicon compounds
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Abstract

A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase. When reactive monomers are allowed to polymerize in the water phase to form particles, the surface of the particles have cavities that are the mirror image of the imprint group.

Claims

1. A molecularly imprinted material comprising an inorganic oxide structure having a plurality of pores or channels, wherein the pores or channels have walls that define a plurality of molecularly imprinted cavities wherein the molecularly imprinted cavities are homogeneous in specificity and reactivity.

2. The molecularly imprinted material of claim 1 wherein the inorganic oxide structure is silica.

3. The molecularly imprinted material of claim 1 wherein the pores or channels are in the size range of about 0.01 μ

m to about 0.5 μ

m.

4. The molecularly imprinted material of claim 1 wherein the walls that define a plurality of molecularly imprinted cavities include a plurality of functional groups in a spaced-about location on the walls of the molecularly imprinted cavities, the spatial location of the functional groups being complementary to the spatial location of complementary functional groups of a predetermined imprint molecule.

5. A composition comprising inorganic oxide particles wherein the suface of each particle defines a plurality of molecularly imprinted cavities wherein the molecularly imprinted cavities are homogeneous in specificity and reactivity.

6. The composition of claim 5 wherein the inorganic oxide particles are silica.

7. The composition of claim 5 wherein the inorganic oxide particles have an average size of between 50 nm and 1200 nm.

8. The composition of claim 5 wherein the surface of each inorganic oxide particle includes a plurality of functional groups in a spaced-about location on the surface of the molecularly imprinted cavities, the spatial location of the functional groups being complementary to the spatial location of complementary functional groups of a predetermined imprint molecule.