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Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

  • US 6,713,452 B2
  • Filed: 06/04/2001
  • Issued: 03/30/2004
  • Est. Priority Date: 06/04/2001
  • Status: Expired due to Fees
First Claim
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1. A substantially monodispersed mixture of conjugates, wherein the conjugate comprises a first oligomer and a second oligomer, wherein each oligomer comprises a polyethylene glycol moiety and is coupled to salmon calcitonin and wherein the first oligomer is covalently coupled to an amine function of Lys11 of the salmon calcitonin and the second oligomer is covalently coupled to an amine function of Lys18 of the salmon calcitonin.

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