Method for the iontophoretic non-invasive determination of the in vivo concentration level of an inorganic or organic substance
First Claim
1. A method of making a component for use in a device for iontophoretic sampling of glucose, said method comprising:
- positioning a positive electrode, a negative electrode, and an electrically insulating material separating the electrodes to present a single common surface; and
positioning a first collection reservoir, comprising an electrically conductive material, to be capable of electrical communication with said positive electrode or said negative electrode to result in making said component for use in said device.
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Abstract
The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises:
(a) a positive electrode;
(b) a negative electrode, and
(c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample.
The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal.
The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.
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Citations
15 Claims
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1. A method of making a component for use in a device for iontophoretic sampling of glucose, said method comprising:
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positioning a positive electrode, a negative electrode, and an electrically insulating material separating the electrodes to present a single common surface; and
positioning a first collection reservoir, comprising an electrically conductive material, to be capable of electrical communication with said positive electrode or said negative electrode to result in making said component for use in said device. - View Dependent Claims (3, 4, 5, 6, 7)
providing the component of claim 1;
providing an analyzing component; and
assembling said component of claim 1 and said analyzing component to make said device.
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6. The method of claim 5, wherein said analyzing component is a biosensor electrode.
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7. The method of claim 6, wherein said biosensor electrode comprises platinum.
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2. The method of claimed 1, further comprising positioning a second collection reservoir, comprising an electrically conductive material, to be capable of electrical communication with said positive electrode or said negative electrode such that said second collection reservoir is capable of electrical communication with an electrode other than the electrode which is capable of electrical communication with said first collection reservoir.
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8. A method of making an iontophoretic device for use in sampling of glucose, said method comprising:
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positioning a positive electrode and a negative electrode;
positioning a first collection reservoir, comprising an electrically conductive material, to be capable of electrical communication with said positive electrode or said negative electrode;
positioning electrical leads for the positive electrode and the negative electrode, said leads capable of creating an electrical circuit;
providing means for correlating a signal from glucose with an amount or concentration of glucose;
providing a display to indicate said amount or concentration of glucose; and
assembling said electrodes, collection reservoir, leads, means for correlating, and display to result in making said iontophoretic device. - View Dependent Claims (9, 10, 11)
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12. A method of making monitoring system for use in sampling of glucose, said method comprising:
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assembling an iontophoretic device comprising;
(A) positioning electrical leads for a positive electrode and a negative electrode and connecting said electrical leads for the positive electrode and the negative electrode to a power supply, said leads capable of creating an electrical circuit;
(B) providing means for correlating a signal from extracted glucose with an amount or concentration of glucose;
(C) providing a display, to indicate said amount or concentration of glucose, and positioning said display in operative communication with said means for correlating; and
(D) assembling said leads, means for correlating, and display to make said iontophoretic device;
assembling a component for use in said iontophoretic device, comprising;
(a) positioning the positive electrode, the negative electrode, and an electrically insulating material separating the electrodes to present a single common surface;
(b) positioning said positive and negative electrodes to be capable of operative communication with said electrical leads;
(c) positioning a first collection reservoir, comprising an electrically conductive material, to be capable of electrical communication with said positive electrode;
(d) positioning a second collection reservoir, comprising an electrically conductive material, to be capable of electrical communication with said positive electrode;
providing an analyzing component in operative communication with said means for correlating; and
assembling said iontophoretic device, said component for use in said iontophoretic device, and said analyzing component to make said monitoring system. - View Dependent Claims (13, 14, 15)
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Specification