Ultrasound therapy head configured to couple to an ultrasound imaging probe to facilitate contemporaneous imaging using low intensity ultrasound and treatment using high intensity focused ultrasound

• US 6,716,184 B2
• Filed: 06/07/2002
• Issued: 04/06/2004
• Est. Priority Date: 09/18/1998
• Status: Expired due to Term

• Current Assignee: Mirabilis Medica, Inc.
• Original Assignee: University of Washington
• Inventors: Vaezy, Shahram, Martin, Roy W., Keilman, George W., Crum, Lawrence A., Fujimoto, Victor Y., Carter, Stephen J.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US10/166,795
• Publication Number:
  US 20030028111A1
• Time in Patent Office: 669 Days
• Field of Search: 600/439, 600/459, 601/2-4
• US Class Current: 601/3
• CPC Class Codes: A61B 2017/4216 Operations on uterus, e.g. endometrium
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4209 by using holders, e.g. positioning frames
• CPC Class Codes: A61B 8/4254 using sensors mounted on the probe
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: A61B 8/4488 the transducer being a phased array
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61B 8/483 involving the acquisition of a 3D volume of data
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.

Claims

1. An ultrasound therapy head adapted to couple to an ultrasound imaging probe, to achieve a combination ultrasound imaging probe and ultrasound therapy head to simultaneously image a treatment site within a patient'"'"'s body using the ultrasound imaging probe, and administer ultrasound therapy to the treatment site within the patient'"'"'s body using the ultrasound therapy head, comprising:

(a) a housing, said housing comprising an orifice having a size and shape adapted to enable said housing to be positioned on a distal end of the ultrasound imaging probe, said orifice having a central axis, such that when said housing is positioned on the distal end of the ultrasound imaging probe, an axis of symmetry of an unmodified imaging plane associated with an imaging transducer incorporated into the ultrasound imaging probe is substantially aligned with the central axis of the orifice;

(b) a high intensity focused ultrasound (HIFU) transducer coupled to said housing, said HIFU transducer having an aperture through which HIFU waves are transmitted, the HIFU transducer being disposed relative to said housing such that when said housing is positioned on the distal end of the ultrasound imaging probe, a focal point of said HIFU transducer is within the unmodified imaging plane; and

(c) an electrical conductor electrically coupled to said HIFU transducer, and adapted to be coupled to a power source, to enable said HIFU transducer to be energized to render the HIFU therapy while the imaging transducer incorporated into the ultrasound imaging probe is energized to provide an ultrasound signal for imaging the treatment site.

2. The ultrasound therapy head of claim 1, wherein said HIFU transducer comprises a relative aperture of between about 1.0 and about 1.75.

3. The ultrasound therapy head of claim 1, wherein said HIFU transducer is pivotally coupled to said housing, such that a position of said focal point relative to said housing is variable by pivoting said HIFU transducer relative to said housing.

4. The ultrasound therapy head of claim 3, further comprising a linkage coupled to the HIFU transducer, said linkage being configured to enable a user to remotely change the position of the HIFU transducer relative to said housing.

5. The ultrasound therapy head of claim 1, wherein said HIFU transducer is substantially enclosed by said housing.

6. The ultrasound therapy head of claim 1, wherein said HIFU transducer is fixedly coupled to the housing, and wherein said housing further comprises a plate configured to releasably secure a flexible envelope to said housing, the flexible envelope being adapted to contain a fluid and substantially encapsulating said HIFU transducer.

7. The ultrasound therapy head of claim 1, wherein the HIFU transducer is disposed relative to said housing such that a longitudinal axis of a beam generated by said HIFU transducer is within the imaging plane.

8. The ultrasound therapy head of claim 1, further comprising a flexible envelope adapted to be filled with a fluid, said flexible envelope substantially encapsulating said HIFU transducer.

9. The ultrasound therapy head of claim 8, wherein the flexible envelope is is disposed relative to said housing so as to substantially encapsulate the imaging transducer of the ultrasound imaging probe, when said ultrasound therapy head is attached to the ultrasound imaging probe.

10. The ultrasound therapy head of claim 1, wherein said housing is configured such that when said housing is positioned on the distal end of the ultrasound imaging probe, a portion of the imaging transducer is covered by a solid portion of said housing, thereby effectively substantially reducing a size of the imaging plane obtainable using the imaging transducer.

11. The ultrasound therapy head of claim 10, wherein an effective size of the imaging plane is reduced by about fifty percent by said solid portion.

12. An ultrasound therapy head adapted to couple to an ultrasound imaging probe, to achieve a combination ultrasound imaging probe and ultrasound therapy head for simultaneously imaging a treatment site within a patient'"'"'s body using the ultrasound imaging probe, and administering ultrasound therapy to the treatment site within the patient'"'"'s body using the ultrasound therapy head, comprising:

(a) a housing, said housing including an orifice having a size and shape adapted to enable said housing to be positioned on a distal end of the ultrasound imaging probe, such that when said housing is positioned on the distal end of the ultrasound imaging probe, a portion of an imaging transducer included in the ultrasound imaging probe is covered by a solid portion of said housing, thereby effectively substantially reducing a size of an imaging plane obtainable using the imaging transducer;

(b) a high intensity focused ultrasound (HIFU) transducer coupled to said housing, said HIFU transducer having an aperture through which HIFU waves are transmitted, the HIFU transducer having a focal point that lies within the reduced imaging plane of the imaging transducer when said housing is positioned on the distal end of the ultrasound imaging probe; and

(c) an electrical conductor electrically coupled to said HIFU transducer, and adapted to be coupled to a power source, to enable said HIFU transducer to be energized to render the HIFU therapy while the imaging transducer of the ultrasound imaging probe is energized to provide a signal for imaging the treatment site.

13. An ultrasound therapy head adapted to couple to an ultrasound imaging probe, to achieve a combination ultrasound imaging probe and ultrasound therapy head for simultaneously imaging a treatment site within a patient'"'"'s body using the ultrasound imaging probe, and administering ultrasound therapy to the treatment site within the patient'"'"'s body using the ultrasound therapy head, comprising:

(a) a housing including;

(i) an orifice having a size and shape selected to enable said housing to be positioned on a distal end of the ultrasound imaging probe, such that when said housing is positioned on the distal end of the ultrasound imaging probe, a portion of an imaging transducer included in the ultrasound imaging probe is covered by a solid portion of said housing, thereby effectively substantially reducing a size of an imaging plane obtainable using the imaging transducer;

(ii) a plate configured to releasably secure a flexible envelope to said housing, the flexible envelope adapted to be filled with a fluid; and

(iii) a plurality of fluid channels configured to convey the fluid used to fill the flexible envelope;

(b) a high intensity focused ultrasound (HIFU) transducer coupled to said housing, said HIFU transducer having an aperture through which HIFU waves are transmitted, the HIFU transducer being substantially encapsulated by the flexible envelope when said plate has secured the flexible envelope to said housing; and

(c) an electrical conductor electrically coupled to said HIFU transducer, and adapted to be coupled to a power source, to enable said HIFU transducer to be energized to render the HIFU therapy while the imaging transducer included in the ultrasound imaging probe is energized to provide a signal for imaging the treatment site.

14. An ultrasound therapy head adapted to couple to an ultrasound imaging probe, to achieve a combination ultrasound imaging probe and ultrasound therapy head for simultaneously imaging a treatment site within a patient'"'"'s body using the ultrasound imaging probe, and administering ultrasound therapy to the treatment site within the patient'"'"'s body using the ultrasound therapy head, comprising:

(a) a housing, said housing including an orifice having a size and shape adapted to enable said housing to be positioned on a distal end of the ultrasound imaging probe, said orifice having a central axis;

(b) a high intensity focused ultrasound (HIFU) transducer coupled to said housing, said HIFU transducer having an aperture through which HIFU waves are transmitted, the HIFU transducer being disposed relative to said housing such that a longitudinal axis of a beam generated by said HIFU transducer forms an obtuse angle with regard to the central axis; and

(c) an electrical conductor electrically coupled to said HIFU transducer and adapted to be coupled to a power source, to enable said HIFU transducer to be energized to render the HIFU therapy while the imaging transducer included in the ultrasound imaging probe is energized to provide a signal for imaging the treatment site.

15. An ultrasound therapy head adapted to couple to an ultrasound imaging probe, to achieve a combination ultrasound imaging probe and ultrasound therapy head for simultaneously imaging a treatment site within a patient'"'"'s body using the ultrasound imaging probe, and administering ultrasound therapy to the treatment site within the patient'"'"'s body using the ultrasound therapy head, comprising:

(a) a housing, said housing including an orifice having a size and shape adapted to enable said housing to be positioned on a distal end of the ultrasound imaging probe, said orifice having a central axis;

(b) a high intensity focused ultrasound (HIFU) transducer coupled to said housing, said HIFU transducer having an aperture through which HIFU waves are transmitted, the HIFU transducer being disposed relative to said housing such that a longitudinal axis of a beam generated by said HIFU transducer forms an acute angle relative to the central axis; and

(c) an electrical conductor electrically coupled to said HIFU transducer and adapted to be coupled to a power source to enable said HIFU transducer to be energized, to render the HIFU therapy while the imaging transducer included in the ultrasound imaging probe is energized to provide a signal for imaging the treatment site.

16. An ultrasound therapy head adapted to couple to an ultrasound imaging probe, to achieve a combination ultrasound imaging probe and ultrasound therapy head for simultaneously imaging a treatment site within a patient'"'"'s body using the ultrasound imaging probe, and administering ultrasound therapy to the treatment site within the patient'"'"'s body using the ultrasound therapy head, comprising:

(a) a housing, said housing including an orifice having a size and shape adapted to enable said housing to be positioned on a distal end of the ultrasound imaging probe, said orifice having a central axis;

(b) a high intensity focused ultrasound (HIFU) transducer coupled to said housing, said HIFU transducer having an aperture through which HIFU waves are transmitted, the HIFU transducer being disposed relative to said housing such that a longitudinal axis of a beam generated by said HIFU transducer forms one of an acute angle and an obtuse angle relative to the central axis; and

(c) an electrical conductor electrically coupled to said HIFU transducer and adapted to be coupled to a power source to enable said HIFU transducer to be energized to render the HIFU therapy while the imaging transducer included in the ultrasound imaging probe is energized to provide a signal for imaging the treatment site.