Antimicrobial urine collection system and methods of manufacturing the same

• US 6,716,200 B2
• Filed: 01/18/2002
• Issued: 04/06/2004
• Est. Priority Date: 01/18/2002
• Status: Expired due to Term

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Lambert, James M., Bracken, Ronald L.
• Primary Examiner(s): Lo, Weilun
• Assistant Examiner(s): Bogart, Michael G.
• Application Number:
  US10/052,766
• Publication Number:
  US 20030139730A1
• Time in Patent Office: 809 Days
• Field of Search: 604/264, 604/265, 604/327, 604/328, 604/346, 604/347-350, 604/355
• US Class Current: 604/265
• CPC Class Codes: A61F 5/441 having venting or deodorant means, e.g. filters ; having antiseptic means, e.g. bacterial barriers
• CPC Class Codes: A61L 28/0011 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 28/0038 Medicaments; Biocides

Abstract

An antimicrobial urine collection system comprising a urine collection bag and tubing each made from a polymer, wherein the polymer comprises therein from about 0.1 to 20 phr of an antimicrobial agent. The antimicrobial agent is preferably a phosphoric acid metal salt, preferably one in which zinc is the metal. The agent can be compounded into the polymer material for forming the system components.

Claims

1. An antimicrobial urine collection system comprising a urine collection bag and tubing coupled to the bag and constructed to transport urine to the bag, the bag and tubing each made from a polymer, wherein said polymer of the bag or tubing is substantially clear and comprises therein from about 0.1 to 20 phr of an antimicrobial agent, said agent substantially resistant to heat up to at least the melting point of said polymer, substantially uniformly distributed therein, said antimicrobial agent not substantially affecting the clarity of the polymer, and exhibiting an antimicrobial effect.

2. The urine collection system according to claim 1, wherein said polymer comprises therein from about 0.5 to 75 phr of an antimicrobial agent.

3. The urine collection system according to claim 1, wherein said polymer comprises therein from about 4.5 phr of an antimicrobial agent.

4. The urine collection system according to claim 1, wherein said polymer is selected from the group of polymers consisting of polyethylene, polypropylene, ethylene vinyl acetate, metallocene catalyzed polyethylene, or blends thereof.

5. The urine collection system according to claim 1, wherein said polymer is polyvinyl chloride.

6. The urine collection system according to claim 1, wherein said polymer of said collection bag comprises from about 0.1 to 20 phr of an antimicrobial agent.

7. The urine collection system according to claim 1, wherein said polymer of said tubing comprises from about 0.1 to 20 phr of an antimicrobial agent.

8. The urine collection system according to claim 1, wherein said polymer of said tubing and said polymer of said collection bag each comprise from about 0.1 to 20 phr of an antimicrobial agent.

10. The urine collection system according to claim 1, wherein said antimicrobial agent is an organic acid metal salt.

9. An antimicrobial mine collection system comprising a urine collection bag and tubing coupled to the bag and constructed to transport urine to the bag, the bag and tubing each made from a polymer, wherein said polymer of said tubing and said collection bag collection bag are each polyvinyl chloride comprising from about 0.1 to 20 phr of an antimicrobial agent that is substantially uniformly distributed therein, said antimicrobial agent not substantially affecting the clarity of the polymer, and exhibiting an antimicrobial effect.

11. An antimicrobial urine collection system comprising a urine collection bag and tubing coupled to the bag and constructed to transport urine to the bag, the bag and tubing each made from a polymer, wherein said polymer of the bag or tubing comprises therein from about 0.1 to 20 phr of an antimicrobial agent that is substantially uniformly distributed therein, wherein said antimicrobial agent is an organic acid metal salt comprising phosphoric acid esters and zinc metal, said antimicrobial agent not substantially affecting the clarity of the polymer, and exhibiting an antimicrobial effect.

12. An antimicrobial urine collection system comprising a urine collection bag and tubing coupled to the bag and constructed to transport urine to the bag, the bag and tubing each made from a polymer, wherein said polymer of the bag or tubing comprises therein from about 0.1 to 20 phr of an antimicrobial agent that is substantially uniformly distributed therein, wherein said antimicrobial agent is an organic acid metal salt comprising from about 0.3 to 5 phr of a phosphoric acid metal salt and in addition, from about 0.2 to 2.5 phr of a stabilizer, said antimicrobial agent not substantially affecting the clarity of the polymer, and exhibiting an antimicrobial effect.

13. An antimicrobial urine collection system comprising a urine collection bag and tubing coupled to the bag and constructed to transport urine to the bag, the bag and tubing each made from a polymer, wherein said polymer of the bag or tubing comprises therein from about 0.1 to 20 phr of an antimicrobial agent that is substantially uniformly distributed therein, wherein said antimicrobial agent comprises from about 0.05 to 15 phr of a phosphoric acid metal salt and in addition, from about 0.1 to 5 phr of a stabilizer, said antimicrobial agent not substantially affecting the clarity of the polymer, and exhibiting an antimicrobial effect.

14. An antimicrobial urine collection system comprising a urine collection bag and tubing coupled to the bag and constructed to transport urine to the bag, the bag and tubing each made from a polymer, wherein said polymer of the bag or tubing comprises therein from about 0.1 to 20 phr of an antimicrobial agent that is substantially uniformly distributed therein, wherein said antimicrobial agent comprises from about 0.3 to 5 phr of a phosphoric acid metal salt and from about 0.2 to 2.5 phr of a stabilizer, said antimicrobial agent not substantially affecting the clarity of the polymer, and exhibiting an antimicrobial effect.

15. An antimicrobial urine collection system comprising a urine collection bag and tubing coupled to the bag and constructed to transport urine to the bag, the bag and tubing each made from a polymer, wherein said polymer of the bag or tubing comprises therein from about 0.1 to 20 phr of an antimicrobial agent that is substantially uniformly distributed therein, wherein said antimicrobial agent comprises from about 3 phr of a phosphoric acid metal salt and from about 1.5 phr of a stabilizer, said antimicrobial agent not substantially affecting the clarity of the polymer, and exhibiting an antimicrobial effect.

16. An antimicrobial urine collection system comprising a catheter joined to tubing and comprising a rubber material, wherein said rubber material comprises therein from about 0.1 to 20 phr of an antimicrobial agent wherein said antimicrobial agent is an organic acid metal salt is comprising phosphoric acid esters and zinc metal.

17. An antimicrobial urine collection system comprising a urine collection bag and tubing coupled to the bag and constructed to transport urine to the bag, the bag and tubing each made from a polymer, wherein said polymer of the bag or tubing comprises therein from about 0.1 to 20 phr of an organic acid metal salt substantially uniformly distributed therein, said organic acid metal salt exhibiting an antimicrobial effect.

18. The urine collection system according to claim 17, wherein said bag or tubing exhibit an effective gram positive, grain negative and yeast zone of inhibition.

19. The urine collection system according to claim 17, further comprising a catheter, said catheter, collection bag and tubing each manufactured in such a way so as to release said antimicrobial agent in a sustained and controlled manner.

20. A method for manufacturing antimicrobial PVC tubing comprising the steps of:

compounding an antimicrobial agent comprising phosphoric acid esters and zinc metal into PVC resin pellets at an effective concentration to provide an antimicrobial effect in the tubing;

placing said pellets into an extruder; and

extruding said pellets through said extruder to form a tube having antimicrobial effectiveness.

21. A method for manufacturing antimicrobial PVC film for use as a urine collection bag comprising the steps of:

compounding an antimicrobial agent comprising phosphoric acid esters and zinc metal into PVC resin pellets at an effective concentration to provide an antimicrobial effect in the film;

placing said pellets into a calendar; and

calendaring said pellets into a thin film to having antimicrobial effectiveness.