Pulmonary vein stent and method for use

• US 6,716,242 B1
• Filed: 10/13/2000
• Issued: 04/06/2004
• Est. Priority Date: 10/13/1999
• Status: Expired due to Term

• Current Assignee: Biocardia Deviceco, Inc.
• Original Assignee: Biocardia Deviceco, Inc.
• Inventors: Altman, Peter A.
• Primary Examiner(s): Isabella, David J.
• Assistant Examiner(s): Chattopadhyay, Urmi
• Application Number:
  US09/687,776
• Time in Patent Office: 1,271 Days
• Field of Search: 623/1-2-, 623/11.11, 623/12, 623/23.7, 606/191-192, 606/194-195, 606/198, 427/2-4-
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2002/821 Ostial stents
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/40 characterised by a specific therapeutic activity or mode of action
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

Ablation of the pulmonary veins causes damage to the tissue which may affect the viability of the tissue. By placing a stent, a vascular endoprosthesis, within a target pulmonary vein it is possible to protect the functionality of the veins after the ablation procedure. Placement of a stent, endoprosthesis or mere circuit interrupting structure into a target pulmonary vein, without ablation, prevents aberrant electrical activity in the pulmonary veins from interfering with the electrical activity of the left atrium. The stent, endoprosthesis or circuit interrupting structure may also be coated or comprised of a drug-eluting compound, loaded with a drug which inhibits arrhythmia.

Claims

1. A drug delivery stent comprising:

a stent; and

a drug-eluting coating on the stent, said drug eluting coating comprising a drug;

the stent having a first longitudinal region through which the drug is eluted and a second longitudinal region through which the drug is not eluted;

wherein the drug is an antiarrhythmic drug.

2. A drug delivery stent comprising:

a stent;

a drug-eluting compound uniformly covering the stent;

a small first longitudinal region of the drug-eluting compound being capable of eluting a drug; and

a cover disposed over a second longitudinal region of the drug eluting compound that prevents elution of a drug from the second longitudinal region;

wherein the drug is an antiarrhythmic drug.

3. A drug delivery stent comprising:

a stent;

a drug incorporated into the stent; and

a coating covering a substantial longitudinal portion of the stent, said coating inhibiting elution of the drug from the stent in said longitudinal portion, the drug being eluted from the portion of the stent not covered by the coating;

wherein the drug is an antiarrhythmic drug.

4. A drug delivery stent comprising:

a stent;

a drug-eluting compound, uniformly covering the stent, the drug-eluting compound comprising a drug; and

a coating covering a first longitudinal portion of the drug-eluting compound, said coating impeding the elution of the drug from the stent, whereby the drug is eluted from the portion of the drug-eluting compound not covered by the coating;

wherein the drug is an antiarrhythmic drug.

5. A drug delivery stent comprising:

a stent having a first longitudinal region and a second longitudinal region;

a first coating disposed on the stent, said first coating capable of eluting a drug;

a second coating disposed on the stent and over the first coating, said second coating capable of inhibiting the drug from eluting;

wherein the second coating covers the first longitudinal region of the stent such that the drug may elute only from the second longitudinal region of the stent;

wherein the drug is an antiarrhythmic drug.

6. A drug delivery stent comprising:

a stent having a first longitudinal region and a second longitudinal region;

a first coating disposed on the stent on the first longitudinal region and the second longitudinal region, said first coating comprising a drug and a compound capable of eluting the drug;

a second coating disposed on the stent and over the first coating, said second coating being impermeable to the drug;

wherein the second coating is limited to the second longitudinal region of the stent such that the drug may elute only from the first longitudinal region of the stent;

wherein the drug is an antiarrhythmic drug.