Delivery on nonsteroidal antiinflammatory drugs through an inhalation route
First Claim
1. A composition for delivery of a nonsteroidal antiinflammatory drug comprising a condensation aerosola) formed by volatizing a nonsteriodal antiinflammatory drug under conditions effective to produce a heated vapor of the drug and condensing the heated vapor of the drug to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% nonsteriodal antiinflammatory drug degradation products, and c) wherein the aerosol MMAD is less than 3 microns.
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Accused Products
Abstract
The present invention relates to the delivery of nonsteroidal antiinflammatory drugs (NSAIDs) through an inhalation route. Specifically, it relates to aerosols containing NSAIDs that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an NSAID. In a method aspect of the present invention, an NSAID is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an NSAID, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an NSAID through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an NSAID; and, b) a device that forms an NSAID aerosol from the composition, for inhalation by the mammal.
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Citations
12 Claims
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1. A composition for delivery of a nonsteroidal antiinflammatory drug comprising a condensation aerosol
a) formed by volatizing a nonsteriodal antiinflammatory drug under conditions effective to produce a heated vapor of the drug and condensing the heated vapor of the drug to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% nonsteriodal antiinflammatory drug degradation products, and c) wherein the aerosol MMAD is less than 3 microns.
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6. A method of producing a nonsteroidal antiinflammatory drug in an aerosol form comprising:
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a) volatilizing a nonsteroidal antiinflammatory drug under conditions effective to produce a heated vapor of the drug, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the drug comprising less than 5% drug degradation products and an aerosol having an MMAD less than 3 μ
m.- View Dependent Claims (7, 8, 9, 10, 11, 12)
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Specification