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Increasing ionization efficiency in mass spectrometry

  • US 6,716,634 B1
  • Filed: 05/31/2000
  • Issued: 04/06/2004
  • Est. Priority Date: 05/31/2000
  • Status: Expired due to Fees
First Claim
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1. A method of analyzing a polyionic molecule by mass spectrometry, the method comprising steps of:

  • providing a polyionic molecule;

    attaching at least one multiply charged tag to the polyionic molecule by a covalent linkage to produce a polyionic molecule/tag adduct, wherein the net charge on the adduct differs from that of the polyionic molecule; and

    analyzing the adduct by mass spectrometry.

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